Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative option for a variety of malignant and non-malignant hematological and congenital diseases. Due to the fact that the human leukocyte antigen system is inherited independently of the blood group system, approximately 40-50% of all HSCTs are performed across the ABO blood group barrier. The expected immune-hematological conseq...

BACKGROUND Elevated serum soluble E-selectin levels have been associated with a number of diseases. Although E-selectin levels are heritable, little is known about the specific genetic factors involved. E-selectin levels have been associated with the ABO blood group phenotype. METHODS AND RESULTS We performed a high-resolution genome-wide association study of serum soluble E-selectin levels i...

BACKGROUND Hypertension is a major health problem, especially because it has no clear symptoms. It is strongly correlated with modifiable risk factors such as adiposities, age, stress, high salt intake. Overweight and obesity is conveniently determined from BMI and visceral adiposity is determined by waist circumference. ABO blood group is one such factor which needs to be investigated. The pre...

Introduction: The increased risk of hemolytic reactions and erythrocyte recovery delay in ABO incompatible hematopoietic stem cell transplantation (HSCT) are well established. Effects of ABO incompatibility on other transplantation outcomes are evaluated in this study. Subjects and Methods: We prospectively followed 501 patients undergoing allogeneic stem cell transplantation regarding their AB...

PURPOSE Additional clinical experience and knowledge regarding the barrier to transplantation of ABO blood type incompatibility could reduce the higher rate of infectious complications in ABO-incompatible kidney transplantation. METHODS A total of 79 ABO-incompatible kidney transplantation (ABOiKT) patients were compared with 260 ABO-compatible kidney transplantation (ABOcKT) patients for bas...

Introduction: Hemolytic disease of the newborn is a clinical condition in which fetal red blood cells are destroyed by maternal allo-antibodies directed red blood cell antigens acquired from the father. Justification: In many developing countries like Zambia, the true incidence of Hemolytic Disease of the New Born is not known. It may be postulated that hyperbilirubineamia due to ABO incompatib...

BACKGROUND & OBJECTIVES There is lack of adequate information on the association between severe malaria and some human genetic markers like ABO blood types. The study was undertaken to evaluate the association between severe malaria infection and ABO blood types among febrile patients attending Felegeselam Health Center, northwestern Ethiopia. METHODS A total of 398 febrile patients were exam...

many investigations have proved relations between abo blood groups with some diseases and factor viii and von willebrand level in plasma. in this study we investigated a relation between abo blood groups and factor viii and ix inhibitors in 102 patients with haemophilia a and 48 patients with haemophilia b. the assay of inhibitor was done by bethesda method. there were no relation between abo b...

Drosophila melanogaster females homozygous for the abnormal oocyte mutation produce a large excess of female offspring when crossed with XY/0 males. After several genera­ tions in abo homozygous stock, this maternal effect is no longer observed. The disappearance of the abo phenotype is coupled with an increase in the amount of DNA coding for rRNA (rDNA). We have used restriction endonuclease a...

OBJECTIVES The best treatment for end-stage renal disease is kidney transplant, but the shortage of donor organs has caused long waiting times for an appropriate organ allograft. The use of ABO-incompatible kidney transplant can be a valuable option to expand the donor pool. The purpose of the present study was to evaluate 13 patients who had successful ABO-incompatible kidney transplant with d...