Background: Trial data often does not cover a sufficiently long period of time to truly capture time-toevent endpoints, however, Health Technology Assessment (HTA) bodies often require overall survival (OS) and progression-free survival (PFS) estimates. Often, significant survival effects are found beyond the time period observed in clinical trials, thus, extrapolation of trial results is requi...

While use of LEDs in fiber optics and lighting applications is common, their use in medical diagnostic applications is very rare. Since the precise value of light intensity will be used to interpret patient results, understanding failure modes is very important. We used the Failure Modes and Effects Criticality Analysis (FMECA) tool to identify the critical LED failure modes. Once the critical ...