نتایج جستجو برای: accumulated damage
تعداد نتایج: 262190 فیلتر نتایج به سال:
Oxidative stress is implicated in various neurodegenerative disorders, including retinitis pigmentosa (RP), an inherited disease that causes blindness. The biological and cellular mechanisms by which oxidative stress mediates neuronal cell death are largely unknown. In a mouse model of RP (rd10 mice), we show that oxidative DNA damage activates microglia through MutY homolog-mediated (MUYTH-med...
Loss of G1/S control is a hallmark of cancer, and is often caused by inactivation of the retinoblastoma pathway. However, mouse embryonic fibroblasts lacking the retinoblastoma genes RB1, p107, and p130 (TKO MEFs) are still subject to cell cycle control: Upon mitogen deprivation, they enter and complete S phase, but then firmly arrest in G2. We now show that G2-arrested TKO MEFs have accumulate...
in this paper, a crack localization method for euler-bernoulli beams via an efficient static data based indicator is proposed. the crack in beams is simulated here using a triangular variation in the stiffness. static responses of a beam are obtained by the finite element modeling. in order to reduce the computational cost of damage detection method, the beam deflection is fitted through a poly...
results of damage prediction in buildings can be used as a useful tool for managing and decreasing seismic risk of earthquakes. in this study, damage spectrum and c4.5 decision tree algorithm were utilized for damage prediction in steel buildings during earthquakes. in order to prepare the damage spectrum, steel buildings were modeled as a single-degree-of-freedom (sdof) system and time-history...
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