1. Carnitine acetyltransferase (EC 2.3.1.7) activity in sheep liver mitochondria was 76nmol/min per mg of protein, in contrast with 1.7 for rat liver mitochondria. The activity in bovine liver mitochondria was comparable with that of sheep liver mitochondria. Carnitine palmitoyltransferase activity was the same in both sheep and rat liver mitochondria. 2. The [free carnitine]/[acetylcarnitine] ...

1. A study of the acyl group specificity of the carnitine acetyltransferase reaction [acyl-(-)carnitine+CoASH right harpoon over left harpoon (-)-carnitine+acyl-CoA] has been made with the enzyme from pigeon breast muscle. Acyl groups containing up to 10 carbon atoms are transferred and detailed kinetic investigations with a range of acyl-CoA and acylcarnitine substrates are reported. 2. Acyl-C...

Introduction Prior mechanistic studies in rodents showed decreased levels of the pivotal mitochondrial metabolite acetyl-L-carnitine (LAC) relation to cognitive deficits and depressive-like behavior (Neuron 2017, 10.1016/j.neuron.2017.09.020, PNAS 2013, 10.1073/pnas.1216100110), providing basis for current translational study. Objectives The main objective this work was ascertain role specific ...

Copyright©2014 Korean Geriatric Society This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/). Vivid Dreaming after Acetyl-L-Carnitine Administration: A Report of Two Cases Hyeyun Kim, MD, Do Young Yoon, MD, Doo Yong Park, MD, Hyun Jeong Han, MD Department of Neurology, Catholic Kwan...

Insulin resistance occurs frequently in patients with chronic kidney disease. However, the mechanisms of insulin resistance associated with chronic kidney disease are unclear. It is known that an increase in the mitochondrial acetyl-CoA (AcCoA)/CoA ratio causes insulin resistance in skeletal muscle, and this ratio is regulated by carnitine acetyltransferase that exchanges acetyl moiety between ...

The aim of this systematic review was to quantify the efficacy of L-carnitine (LC) and/or L-acetyl-carnitine (LAC) in nutrition treatment for male infertility according to present clinical evidence. Biomedical databases were searched to collect related clinical trials and nine relevant randomized controlled trials (RCTs) were included. The quality of the RCTs was assessed based on their perform...

The sparse-fur (spf) mutant mouse has an X-linked deficiency of hepatic ornithine transcarbamylase (OTC), and devetops hyperftmmonemia immediately after weaning and maintains it throughout its life span. We haye studied the effects of acetyl-L-carnitine (ALCAR) on the hepatic mitochondrial proteins of the chronicaJly hyperammonemic spf mice. Two different age groups of mice were studied, the we...

Pyruvate and acetyl-coenzyme A, located at the interface between glycolysis and TCA cycle, are important intermediates in yeast metabolism and key precursors for industrially relevant products. Rational engineering of their supply requires knowledge of compensatory reactions that replace predominant pathways when these are inactivated. This study investigates effects of individual and combined ...

background and aim: in skeletal muscle, carnitine plays an essential role in the translocation of long-chain fatty-acids into the mitochondrial matrix for subsequent beta-oxidation. despite an abundance of literature describing the basic mechanisms of action of l-carnitine metabolism, there remains some uncertainty regarding the effects of oral l-carnitine supplementation on metabolism and exer...

Background: The benefit effect of L-carnitine is proposed for treatment of obesity as long time periods. So, in the present study, effect of L-carnitine on serum FSH, LH and testosterone levels in adult male rats is evaluated. Materials and Methods: Rats were treated different doses of L-carnitine tartarate daily for 16 days, peritoneally. The control group was treated saline as vehicle. After ...