Abstract The purpose of this study was to explore the inhibitory effect α-methyl-5- hydroxytryptamine (α-methyl-5-HT) on ATP-activated current (IATP) in rat dorsal root ganglion (DRG) neurons. Whole-cell patch clamp experiment performed cultured DRG One minute after treatment with α-methyl-5-HT, ATP (10-4 mol/L) activation neurons inhibited. However, independent caused by α-methyl-5-HT. dose-re...

GPR18, GPR55 and GPR119 (provisional nomenclature), although showing little structural similarity to CB1 CB2 cannabinoid receptors, respond endogenous agents analogous the ligands, as well some natural/synthetic receptor ligands [104]. Although there are multiple reports indicate that can be activated in vitro by N-arachidonoylglycine, lysophosphatidylinositol N-oleoylethanolamide, respectively...

Abstract SARS-CoV-2 attacks various organs, most destructively the lung, and cellular entry requires two host cell surface proteins: ACE2 TMPRSS2. Downregulation of one or both these is thus a potential therapeutic approach for COVID-19. TMPRSS2 known target androgen receptor, ligand-activated transcription factor; receptor activation increases levels in tissues, notably prostate. We show here ...

Motilin receptors (provisional nomenclature) are activated by motilin, a 22 amino-acid peptide derived from precursor (MLN, P12872), which may also generate motilin-associated peptide. There significant species differences in the structure of motilin and its receptor, functions motilin. In humans large mammals such as dog, activation these released endocrine cells duodenal mucosa during fasting...

Moth pheromones cause rises in intracellular Ca(2+) concentrations that activate Ca(2+)-dependent cation channels in antennal olfactory receptor neurons. In addition, mechanisms of adaptation and sensitization depend on changes in cyclic nucleotide concentrations. Here, cyclic nucleotide-activated currents in cultured olfactory receptor neurons of the moth Manduca sexta are described, which sha...

Nicotinic acid is used to treat dyslipidemia from the past few decades. has capability increase plasma HDL cholesterol concentration, and so it being as a potential pharmacological agent. an unwanted side effect called flushing, which patients compliance this unpleasant . With help of receptor GPR109A for nicotinic possible understand underlying mechanism action effects acid, helped in maximizi...