The microtubule assembly-promoting activity of different pools of tau protein isolated from Alzheimer disease (AD) and control brains and the effect of dephosphorylation on this activity were studied. Tau isolated from a 2.5% perchloric extract of AD brain had almost the same activity as that obtained from control brain, and this activity did not change significantly on dephosphorylation. Abnor...

Dissipative time crystals can appear in spin systems, when the ${Z}_{2}$ symmetry of Hamiltonian is broken by environment, and square total operator ${S}^{2}$ conserved. In this paper, we relax latter condition show that time-translation-symmetry-breaking collective oscillations persist, thermodynamic limit, even absence symmetry. We engineer an ad hoc Lindbladian using power-law-decaying opera...

Petri net variants are widely used as a workflow modelling technique. Recently, UML activity diagrams are used for the same purpose, even though the syntax and semantics of activity diagrams has not been yet fully worked out. Nevertheless, activity diagrams seem very similar to Petri nets and on the surface, one may think that they are variants of each other. To substantiate this claim, we need...

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Despite decades of study, effective treatments for AD are lacking. Mitochondrial dysfunction has been closely linked to the pathogenesis of AD, but the relationship between mitochondrial pathology and neuronal damage is poorly understood. Sirtuins (SIRT, silent mating type information regulation 2 homolog in yeast) are NA...

As a form of accountability in carrying out its duties, functions, and authority, a government agency must prepare a budget and work plan. The budgeting process in many government agencies utilizes manual processes with various documents, resulting in long processing time, numerous errors, and difficulty in data searching. Furthermore,the lack of data integration interferes with the need to mee...

Recently, Activity Based Costing (ABC) and ABM (Activity Based Management) have gotten a lot of attention. This paper’s target is the realization of production resource management based on ABM. In order to realize ABRM (Activity Based Resource Management), the analysis of “Activity” and the development of “Monitoring system” are necessary. “Monitoring system” measures the amount of each activit...

An exogenous supply of bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factors 165 (VEGF165) will synergize to promote bone regeneration in vivo. The aim of this study was to confirm the role of VEGF165 on the osteogenesis potential of bone mesenchymal stem cells (BMSCs) transduced by adenovirus vector containing BMP2 gene in vitro.Rabbit BMSCs were isolated and transfected ...

Background Alzheimer’s Disease (AD) is the most prevalent disease among all dementias, and characterized by progressive deficits in cognitive function activities of daily living.The aim this study was compare effects multimodal physical activity program functional capacity, memory, attention elderly with without AD. Method Eighteen AD were ramdomized into control (AD-C) or (AD-T) groups. Also t...

A translation from activity diagrams to class diagrams, with executable code, is presented. The translation is amenable to be made with or without automating tools. An illustrative application example is also briefly presented: Activity diagrams are used in the modelling and implementation of graphical user interfaces, more precisely in the controller part of the Model-View-Controller pattern.