background: the development of toxicity tests regarding toxic responses of different fish species could be more effectively used in predictive toxicology and risk assessment. in this study lethal concentrations (lc50-96 h) values of copper sulphate an important toxic industrial pollutant, on capoeta fusca were determined. behavioral changes at different concentrations of cuso4 were determined f...

acute liver failure (alf) is an uncommon, devastating syndrome of which over 2000 cases occur annually in the usa, with a mortality rate of about 80%. alf is de_ned by the sudden onset of hepatic encephalopathy and coagulopathy (inr_1.5) in an otherwise healthy person. the most common etiologies are acute viral hepatitis a and b, medication overdose (e.g., acetaminophen) and idiosyncratic drug ...

the aqueous and ethanolic extracts of pedalium murex (pedaliaceae) was investigated for antipyretic activity in rats using brewer’s yeast-induced pyrexia models. brewer’s yeast (15%) was used to induce pyrexia in rats. both the extract (200 and 400 mg/kg body weight p.o produced a significant (p

the effects of hydroalcoholic extract (he) of curculigo orchioides gaertn. rhizome (hypoxidaceae) and its alkaloidal and non-alkaloidal fractions (af) and (naf) were evaluated in carrageenan-induced paw edema experimental models of inflammation. the oral administration of he, their af and naf fractions were used at doses of 100, 300 and 500 mg/kg. the effect produced by the he, af and naf fract...

Ficus thonningii is an African ethnomedicine plant used to treat a number of diseases. The nutritional, phytochemical, and pharmacological aspects F. in relation its therapeutic purposes are numerous. contains alkaloids, terpenoids, flavonoids, tannins, active proteins, proteins. Continue identify, isolate, quantify the ingredients, as well their medicinal purposes. Chronic toxicity, toxicology...

Background: Urticaria is a common skin disease characterized by transient and itchy swelling. The spectrum of etiologic factors in urticaria is very wide and contains external factors such as drugs, foods and internal diseases such as infections, SLE, hormonal factors and even lymphoma. Objective: To determine different kinds of urticaria and different etiologic and prevocational factors in pat...

lead is a common toxic agent which impairs various organs functions of the body. the basis of this toxicity is believed to be the negative influence on enzymatic system of cells. in the past few years, increasing consideration has been given to interactions occurring between lead and some essential metals including se and zn. based on the finding that some trace elements could reverse the toxic...

Acute, subacute, and chronic toxicity studies, carcinogenicity bioassays, and reproductive and genetic toxicology studies were performed with quinapril, an ACE inhibitor used in the treatment of hypertension. Acute toxicity is minimal in rodents, and repeated dosing elicits gastric irritation, juxtaglomerular apparatus (JGA) hypertrophy and hyperplasia and tubular degenerative changes in the ki...