To the Editor: We are encouraged by the results of the Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands (MR CLEAN) by Berkhemer et al. (Jan. 1 issue)1 and the thoughtful editorial by Hacke that outlines the window of opportunity to improve stroke trials.2 One possibility is targeting patients with reversible ischemia rather than random...

BACKGROUND AND PURPOSE The accuracy of diffusion-weighted imaging (DWI) for the diagnosis of acute cerebral ischemia among patients with suspected ischemic stroke arriving to an emergency room has not been studied in depth. METHODS DWI was performed in 712 patients with acute or subacute focal symptoms that suggested an acute ischemic stroke (AIS), 609 of them with AIS. RESULTS DWI demonstr...

Acute ischemic stroke is a common and serious neurological disease. Oxygen therapy has been shown to increase oxygen supply to ischemic tissues and improve outcomes after cerebral ischemia/reperfusion. Normobaric hyperoxia (NBO), an easily applicable and non-invasive method, shows protective effects on acute ischemic stroke animals and patients in pilot studies. However, many critical scientifi...

A review is given of the normal regulation of cerebral blood flow (CBF) and its pathophysiology in hypertension and stroke. In otherwise healthy hypertensive patients, the absolute level of CBF is the same as in normal subjects. CBF autoregulation, however, is shifted towards higher pressure, thus impairing the tolerance to hypotension. In most patients, this does not interfere with the benefic...

As part of the extracellular matrix (ECM), perineuronal nets (PNs) are polyanionic, chondroitin sulfate proteoglycan (CSPG)-rich coatings of certain neurons, known to be affected in various neural diseases. Although these structures are considered as important parts of the neurovascular unit (NVU), their role during evolution of acute ischemic stroke and subsequent tissue damage is poorly under...

130 A retrospective study of patients with acute myocardial ischemia syndrome, mainly middle-aged and elderly women, was published in july 2001. The main features of acute myocardial ischemia were typical triggering circumstances, initial ECG mimicking acute myocardial infarction (AMI with transient appearance of Q waves and large negative T waves), mild or no enzymatic changes, and a combinati...

conclusions our findings indicate that fullerenol nanoparticles decrease the brain infarction through enhancement of the sod activity during cerebral ischemia-reperfusion injury. results occlusion of mca induced considerable infarction and lesion in ischemic hemispheres of control ischemic rats (527 ± 59 mm3) in accompany with a decrease in the glutathione content (45%), and sod activity (29%) ...