Liver transplantation is the only treatment available for acute liver failure. However, mortality rates remain high because of the shortage of donor organs. Indeed up to 20% of patients with acute liver failure may survive without transplantation. In the last two decades, research has focused on the development of alternative or supportive measures to deal with acute liver failure; one of the m...

HYPOTHESIS A reproducible and potentially reversible model of acute liver failure in the pig is feasible based on transient ischemia of the liver. DESIGN To determine the shortest period of liver ischemia sufficient to cause 100% mortality, ischemia of the liver was induced for different lengths of time, starting with 6 hours. If the pig survived, ischemia time was prolonged for 2 hours in th...

Acute liver failure is a clinical condition associated with high mortality despite recent technological advances. Supportive devices such as the Molecular Adsorbents Recirculating System (MARS) provide therapeutic strategies to add time to find an organ for orthotopic liver transplantation or to allow the native liver to recover sufficiently to make transplantation unnecessary. In this series o...

1. Discuss the etiology, symptomotology and treatment of biliary atresia 2. Discuss the etiology of portal hypertension and manifestations of liver failure that lead to indications for liver transplantation. 3. Formulate a differential diagnosis for acute renal failure in patients with liver failure and understand treatment options 4. Describe the intraoperative stages of liver transplantation ...

Triggering receptor expressed on myeloid cells-1 (TREM-1) is an important inflammation-related biomarker. The present study aimed to determine whether this affects the short-term prognosis of patients with acute-chronic liver failure (ACLF).