Serum LDH levels have been found to be significantly increased in non-Hodgkin lymphoma (NHL) patients, both histiocytic and lymphocytic. The duration of survival of NHL negatively correlates with the level of serum lactic dehydrogenase (LDH), and statistical analysis reveals that patients with lower levels of LDH have a longer survival rate than the patients with higher LDH activity, irrespecti...

Mantle cell lymphoma (MCL) represents 6% of all cases of B-cell non-Hodgkin lymphoma (NHL) and affects approximately 4,000 persons each year in the United States.[1,2] Similar to chronic lymphocytic leukemia, MCL expresses the mature B-cell markers CD19 and CD20 and aberrantly expresses CD5, a characteristic T-cell marker.[3] These pathologic characteristics shrouded the diagnosis of MCL until ...

Over the past 2 to 3 decades, the outlook for diverse types of acute leukemias has changed from rapidly fatal to potentially curable diseases. This gratifying change is mainly applicable to childhood acute lymphocytic leukemia (ALL) patients, where more than 70% enjoy greater than 5-year survival, but also holds true for some adults (in particular those under the age of 60) with acute myelogeno...

OBJECTIVE To determine the frequency of various types of malignant lymphoma (ML) in the Al-Qassim region of Kingdom of Saudi Arabia (KSA) according to recently introduced the WHO classification. METHODS For this retrospective analysis, material was available in 385 out of 519 cases diagnosed as ML from 1988-2007. Morphological assessment was followed by immunohistochemistry using a panel of a...

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) differs in histological and clinical presentation from classical Hodgkin lymphoma (cHL). The typical morphologic signs of NLPHL are atypical "lymphocytic and histiocytic" (L&H) cells, which are surrounded by a non-neoplastic nodular background of small lymphocytes of B-cell origin. The NLPHL cells are positive for CD45, CD19, CD20, CD22 an...

Autoimmune hemolytic anemia (AIHA) has been associated with chronic lymphocytic leukemia, non-Hodgkin lymphoma, and classical Hodgkin lymphoma, but to the best of our knowledge, the association of AIHA and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) has not been reported previously. A 20-year-old woman presented with conjunctival jaundice, fever, asthenia, and hemoglobin 9.2 g/dL re...

Background: Previous studies have pointed to the major role of viruses in pathogenesis cancers, especially lymphoproliferative cancers. Objectives: The current study investigated relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. Methods: From January 2011 December 2012, we entered every new case acute lymphoblastic leukemia, non-Hodg...