Myeloid sarcoma is an extramedullary tumor of malignant myeloid cells often associated with acute myeloid leukemia, chronic myeloproliferative disorders and myelodysplastic syndromes. The skin is one of the most commonly affected sites. We report a rare case of cutaneous myeloid sarcoma associated with chronic myeloid leukemia.

The prognosis of elderly patients with acute myeloid leukemia is poor, especially when they have associated diseases that affect their performance status. Azacitidine, decitabine, and low-dose cytosine arabinoside are drugs of choice for the treatment of unfit patients with acute myeloid leukemia. Their combination with other adjuvant drugs worth to be studied, in order to increase the therapeu...

Oncoprotein E2a/Pbx1 is produced by the t(1;19) chromosomal translocation of human pre-B acute lymphoblastic leukemia. E2a/Pbx1 blocks differentiation of primary myeloid progenitors but, paradoxically, induces apoptosis in established pre-B-cell lines, and no transforming function of E2a/Pbx1 has been reported in cultured lymphoid progenitors. Here, we demonstrate that E2a/Pbx1 induces immortal...

OBJECTIVE Aberrant activation of transcription factor genes is the most frequent target of genetic alteration in lymphoid malignancies. The lymphoblastic leukemia-derived sequence 1 (LYL1) gene, which encodes a basic helix-loop helix, was first identified with human T-cell acute leukemia. Recent studies suggest its involvement in myeloid malignancies. We aimed to study the expression percent of...

REFERENCES 1. Wang SA, Hasserjian RP. Erythroid proliferations in myeloid neoplasms. Hum Pathol 2012;43:153-64. 2. Liu W, Hasserjian RP, Hu Y, et al. Pure erythroid leukemia: a reassessment of the entity using the 2008 World Health Organization classification. Mod Pathol 2011;24:375-83. 3. Liu CJ, Hong YC, Yang CF, et al. Clinicopathologic features and outcome of acute erythroid leukemia based ...

Homogeneously staining regions (HSR) or double minute chromosomes (dmin) are autonomously replicating extra-chromosomal elements that are frequently associated with gene amplification in a variety of cancers. The diagnosis of leukemia patients was based on characterization of the leukemic cells obtained from bone marrow cytogenetics. This study report two cases, one with Acute Myeloblastic Leuk...

We describe a 40-year-old woman with a history of precursor T-cell acute lymphoblastic leukemia who developed an orbital mass associated with diffuse infiltration of the paranasal sinuses. The clinical and radiologic findings suggested an orbital abscess. Examination of orbital and ethmoid sinus biopsy specimens revealed relapse of precursor T-cell acute lymphoblastic leukemia. Although orbital...

Background: Flow cytometric analysis of leukemias improves accuracy for distinguishing acute leukemias of myeloid and lymphoid origin. In rare cases, both myeloid and lymphoid antigens are expressed, creating ambiguity for lineage assignment and difficulties in diagnosis of leukemia. Aberrant antigen expression in acute myeloid leukemia (AML) is recognized to be a poor prognostic indicator. CD7...

Abstract Introduction/Objective Myeloid/lymphoid neoplasms with rearrangement of FGFR1 are uncommon and heterogeneous group hematological malignancies that may present as myeloproliferative neoplasm, acute myeloid leukemia, T or B lymphoblastic lymphoma/leukemia, mixed phenotypic leukemia. Patients can lymphadenopathy, mediastinal mass, systemic symptoms. Eosinophilia is common in peripheral bl...

Haematologica vol. 85(4):April 2000 2. Borgström GH, Vuopio P, De la Chapelle A. Polyploidy of the bone marrow. Scand J Haematol 1976; 17:12331. 3. Espinet B, Solè F, Woessner S, Florensa L, Besses C, Sans-Sabrafen J. Two new cases of near-tetraploidy in adult acute myeloid leukemia. Cancer Genet Cytogen 1998; 102:131-4. 4. Lemez P, Michalova K, Zemanova Z, et al. Three cases of near-tetraploid...