Background and Objectives: In spite of large number of studies conducted so far, sudden cardiac death remains an enigma and relative importance of acute coronary events as a trigger of sudden death is currently unclear. An autopsy study of heart was therefore planned to observe various histomorphological cardiac changes, and to determine the frequency association of acute coronary events and my...

Abstract Background A limitation of the current guidelines timing invasive coronary angiography (ICA) for patients with non-ST-segment elevation (NSTE) acute syndrome is based on randomization time. So far, no study has reported clinical outcomes strategy time symptom onset. Herein, we aimed to investigate effect from onset 3-year NSTE myocardial infarction (MI). Methods and results Among 13,10...

background :impact of substance abuse on outcome of hospitalized patients with acute myocardial infarction (mi) is a frequent question. available studies show disagreements over its impact, thus we performed this study to find a clear answer.   methods : in a cross sectional study, 304 patients (include 152 consecutive opium dependents and equal number of independents) with acute mi admitted to...

Background Mitral annular plane systolic excursion (MAPSE) is known to have prognostic importance in the risk stratification of patients with acute myocardial infarction (MI). In post-MI patients with MAPSE<8mm, the combined mortality and hospitalization incidence is 43.8%. Similarly, CMR studies have shown that intra-myocardial haemorrhage (IMH) in the infarct core is an independent marker of ...

Background In patients with acute myocardial infarction (AMI) the myocardial salvage index (MSI) quantified by Cardiovascular Magnetic Resonance (CMR) is defined as the volumetric difference of myocardial edema, reflecting the perfusion bed, and the infarcted tissue. While after a coronary occlusion time of more than 8 hours, relevant myocardial salvage is highly unlikely, previous data however...

Right ventricular (RV) involvement after acute myocardial infarction (MI) carries an adverse prognosis, but in the majority of patients RV function recovers fully over time.1 It is believed that the lower oxygen requirement of the RV and higher collateral flow make the RV more resistant to ischemia. In the absence of infarction, myocardial ischemia leads to intracellular and subsequently extrac...

there is a misconception among our people that opioids may prevent or have ameliorating effects in the occurrence of cardiovascular diseases. in this study we evaluated 556 consecutive male patients hospitalized due to acute myocardial infarction (mi) in city of yazd, from may 2000 to october 2001 and compared the characteristics of opium addicts to non opium users. prevalence of opium addictio...

Central to our understanding of acute myocardial infarction (MI) is the tight relationship between myonecrosis and the presence of elevated serum levels of certain enzymes known to originate from within myocardial cells. Together with presence of either chest discomfort or typical electrocardiographic (ECG) changes, an elevation in cardiac enzymes confirms the diagnosis of acute MI. Recently, e...

We have previously shown in patients after recovery from a myocardial infarct (post-MI) that the heparin neutralizing activity (HNA) in the plasma is raised and that this activity may come from platelet factor 4 derived from activated platelets. This report concerns 89 patients admitted with acute chest pain; in 54, with evidence of acute infarction, the level of HNA is much higher than in a po...

Background Changes in left ventricular compliance caused by diffuse fibrosis after MI may result in diastolic dysfunction and left atrial enlargement. We sought to test the hypothesis that left atrial volume is associated with ECV (a marker of diffuse myocardial fibrosis) during the sub-acute phase of infarction and can predict the increase of ECV during the ensuing months of infarct healing. W...