The clinical presentation of acute leukemia results from infiltration of bone marrow or extramedullary sites by blasts. As a result, initial symptoms may be due to the presence of anemia, neutropenia, or thrombocytopenia. Patients generally present with nonspecific complaints including weakness, lethargy, fatigue, dyspnea, fever, weight loss, or bleed‐ ing. Blasts may also infiltrate organs or ...

Russell’s viper and hump-nosed are deadly venomous Viperidae snakes in Sri Lanka. Both these vipers widely distributed all climatic zones of the island. causes systemic envenoming such as coagulopathy, neuroparalysis acute kidney injury (AKI) whilst frequently local rarely AKI coagulopathy. These two may cause atypical syndromes like thrombotic microangiopathy (TMA) hemolytic uremic syndrome (H...

Hantaviruses are viruses belonging to the Bunyaviridae family, and they cause two forms of acute illness in humans: hemorrhagic fever with renal syndrome (HFRS) hantavirus cardiopulmonary (HCPS). HFRS form seen our country progresses fever, kidney injury, thrombocytopenia bleeding. Therefore, infections should be kept mind differential diagnosis patients presenting these symptoms signs. This re...

We describe the case of a 14-year-old Caucasian male, a resident in the Democratic Republic of the Congo, who was observed in Portugal with severe Plasmodium falciparum malaria with high-level parasitemia and severe thrombocytopenia. The course was complicated by bilateral sixth cranial nerve palsy during acute malaria, followed by the appearance of delayed cerebellar ataxia during the recovery...

totally implantable venous access devices (tivad) or implantable catheter ports are devices which can be implanted subcutaneously. they enable prolonged and repeated access to the vascular system, into the peritoneal cavity or intravertebral space. this device is particularly useful for repeated medical injection, for blood sampling or transfusion of blood and blood derivatives and for total pa...

A 6-year-old previously healthy female from the United States presented with 5 days of high fever to 103F, abdominal pain, and vomiting. Exposure history included recent travel Russia, Turkey, Yosemite, San Diego Zoo, as well multiple mosquito bites. On admission, she was found have thrombocytopenia, hematuria, nephrotic range proteinuria subsequently developed acute kidney injury. Her grandfat...

Animal models of thrombocytopenia are indispensable for evaluating the in vivo efficacy of hemostatic agents, cryopreserved platelets, and artificial platelets, but no large animal models are available. In this study, we generated a swine model of acute thrombocytopenia with prolonged bleeding times by administering the chemotherapeutic drug busulfan. First, we tested multiple doses of busulfan...

The haemolytic uraemic syndrome is an acute illness characterised by the occurrence of renal injury, haemolytic anaemia with red cell fragmentation and thrombocytopenia. Haemorrhagic diathesis, arterial hypertension and neurological manifestations often complicate the acute phase of the disease. In this article, we shall discuss in more detail the aspects of this phase. Data obtained in 72 pati...