Pure trigeminal motor neuropathy was first described by China in 1988 [1]. It is a kind of trigeminal motor paralysis disease, which is unaccompanied by trigeminal sensory or any other cranial nerve disturbances. Generally, patients complain about pain and masticatory disability. The morbidity presents low rate. According to literature, less than 20 cases of pure trigeminal motor neuropathy hav...

Inflammation is portion of the body's immune response and it is basically a host protective response to tissue ischemia, injury, autoimmune responses or infectious agents. Although the information presented so far points to a detrimental role for inflammation in central nervous system (CNS) disease, it may also be useful. CNS demonstrates characteristic of inflammation, and in response to damag...

Trigeminal neuralgia is a common cause of facial pain. It has a significant impact on the quality of life and the socioeconomic functioning of the patient. The aim of this review is to provide recommendations for medical management of trigeminal neuralgia based on current evidence. Based upon the analyses of the literature combined with experience in pain management, symptoms, assessment, diffe...

conclusions this study demonstrated improved analgesic effects after using intravenous patient controlled analgesia with ketamine on postoperative pain in opium abusers. patients and methods after institutional review board approval for ethical considerations, a randomized double-blinded placebo controlled clinical trial was conducted. a total of 140 male patients aged 18-65 years, undergoing o...

introduction: headache is the most common neurologic symptom among referees to the emergency department (ed), while the best treatment has not yet been found. therefore, in the present study pain relief effects of metoclopramide and acetaminophen were compared in patients suffered acute primary headache. methods: this study was a double-blind randomized clinical trial performed in imam khomeini...

conclusions intravenous paracetamol appears to provide better analgesia than intravenous morphine in acute limb trauma. further larger studies are required. objectives this study was conducted to compare intravenous paracetamol and intravenous morphine sulfate for acute pain reduction in patients with limb trauma. patients and methods in a randomized double-blinded clinical trial, all patients ...

BACKGROUND Hyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets. KCNQ channels, a subfamily of voltage-gated K(+) channels mediating M-currents, play a key role in neuronal excitability. It is unknown whether KCNQ channels are involved in the excitability of nocicept...

BACKGROUND Dry mouth is known to cause severe pain in the intraoral structures, and many dry mouth patients have been suffering from intraoral pain. In development of an appropriate treatment, it is crucial to study the mechanisms underlying intraoral pain associated with dry mouth, yet the detailed mechanisms are not fully understood. To evaluate the mechanisms underlying pain related to dry m...

BACKGROUND Trigeminal neuralgia (TN) is a rare severe unilateral facial pain condition. Current guidelines in trigeminal neuralgia management recommend sodium channel blockers--carbamazepine or oxcarbazepine--as the first-line treatment. However, the currently available drugs are often associated with poor tolerability resulting in sub-optimal pain control. CNV1014802 is a novel sodium channel ...

BACKGROUND Mechanical and in particular tactile allodynia is a hallmark of chronic pain in which innocuous touch becomes painful. Previous cholera toxin B (CTB)-based neural tracing experiments and electrophysiology studies had suggested that aberrant axon sprouting from touch sensory afferents into pain-processing laminae after injury is a possible anatomical substrate underlying mechanical al...