Patients: 1124 critically ill adults who were ≥ 18 years of age (mean age 60 y, 71% men), had acute kidney injury due to acute tubular necrosis, required RRT, and had sepsis or failure of ≥ 1 nonrenal organ system. Exclusion criteria included baseline serum creatinine > 2 mg/dL (177 μmol/L) in men or > 1.5 mg/dL (133 μmol/L) in women, previous kidney transplantation, pregnancy, and short life e...

High doses of colistin were used in the treatment of severely ill patients with refractory klebsiella chest and urinary tract infections. At the same time renal function was monitored to determine possible nephrotoxicity. In all patients it produced acute renal failure and in some acute tubular necrosis. Though renal failure contributed to the final cause of death in some cases, in the majority...

Acute kidney injury (AKI) is a common and important medical problem, affecting 10% of hospitalized patients, and it is associated with significant morbidity and mortality. The most frequent cause of AKI is acute tubular necrosis (ATN). Current imaging techniques and biomarkers do not allow ATN to be reliably differentiated from important differential diagnoses, such as acute glomerulonephritis ...

PURPOSE Management of acetaminophen overdose focuses on the risk hepatic failure. However, acute renal failure, although less frequent, can lead to serious metabolic complications and require hemodialysis. We report three cases of acute renal failure related to acetaminophen overdose. CLINICAL FEATURES Three patients, aged 17-46 yr ingested acetaminophen 19 to 32 g, and were admitted to the i...

Malaria is one of the leading causes of acute renal failure in south-east Asia especially India and Vietnam, and Africa1. Plasmodium vivax is the predominant malarial parasite in India accounting for 50.4– 56.4% cases in the last five years2. Falciparum malaria is the more severe variant of malaria in the region commonly associated with renal complications. Renal manifestations described in fal...

Fluid convection and mixing induced by bubble-propelled tubular microengines are characterized using passive microsphere tracers. Enhanced transport of the passive tracers by bubble-propelled micromotors, indicated by their mean squared displacement (MSD), is dramatically larger than that observed in the presence of catalytic nanowires and Janus particle motors. Bubble generation is shown to pl...

A 38-year-old male was admitted with fever, progressive jaundice, cervical lymphadenopathy, hepatomegaly and acute oliguric renal failure. Epstein-Barr virus (EBV) infection was diagnosed by detection of EBV-DNA in plasma and confirmed by EBV seroconversion. Kidney biopsy revealed acute tubular necrosis and abundant casts, consisting of bilirubin pigment. With conservative treatment, the patien...

Mouse adenovirus causes a persistent infection in the mouse kidney that produces extensive mononuclear cell infiltrates in cortex and medulla. Tubular necrosis, dilatation, and occasional collapse occur but no glomerular changes or periglomerular fibrosis have been observed. Acute and chronic adenovirus infection of the kidney predispose the kidney to develop acute pyelonephritis when the mouse...

ACEi – Angiotensin Converting Enzyme inhibitors, AKI – Acute Kidney Injury, ARB – Angiotensin Receptor Blockers, ATN – Acute Tubular Necrosis, BP – Blood Pressure, CKD – Chronic Kidney Disease, eGFR – estimated Glomerular Filtration Rate, ESRD – End Stage Kidney Disease, GAIN – Guidelines and Audit Implementation Network, GFR – Glomerular Filtration Rate, MAP – Mean Arterial Pressure, NCEPOD – ...

Background: The widely adopted Jablonski scoring system for reporting histological damage in kidney ischaemia reperfusion injury (IRI) provides a limited score documenting the degree of necrosis within tubular cells. IRI is a complex process that involves damage to various cellular components of the renal cortex and therefore there is a need to develop a more detailed scoring system. The aims o...