نتایج جستجو برای: ad 40
تعداد نتایج: 415783 فیلتر نتایج به سال:
Background Cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarkers are used to clinically diagnose AD with an accuracy of 70-80%. However, they invasive and expensive need be further studied on preclinical-AD. Additionally, a blood-based biomarker can great use. In order obtain biomarker, we have sequenced plasma cell-free RNA (cfRNA) from preclinical-AD individuals develop prediction mod...
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, hallmarked by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Due to uncertainty pathogenesis AD, strategies aimed at suppressing neuroinflammation fostering synaptic repair are eagerly sought. Asiaticoside (AS), natural triterpenoid derivative derived from Centella asiatica, known for its anti-inflammat...
BACKGROUND Hyper-IgE syndromes (HIES) are primary immunodeficiency disorders characterized by Staphylococcus aureus abscesses, recurrent pneumonia, increased serum IgE levels, and eczema. The association of heterozygous signal transducer and activator of transcription 3 (STAT3) mutations with autosomal dominant (AD)-HIES allows the differentiation of AD-HIES from disorders associated with eczem...
Alzheimer disease (AD) primarily affects older adults. This neurodegenerative disorder is the most common cause of dementia and is a leading source of their morbidity and mortality. Patient care costs in the United States are about 200 billion dollars and will more than double by 2040. This case report describes the remarkable improvement in a patient with advanced AD in hospice who received 5 ...
BACKGROUND [18F]THK5351, a recently-developed positron emission tomography (PET) tracer for measuring tau neurofibrillary tangle accumulation, may help researchers examine aging, disease, and tau pathology in living human brains. We examined THK5351 tracer pharmacokinetics to define an optimal acquisition time for static late images. METHODS Primary measurements were calculation of regional v...
Gait disturbance is common in patients with Alzheimer's disease (AD). The aim of this study was to analyse the clinical gait syndromes of patients with AD using Nutt's classification. Fifty-five patients who satisfied the NINCDS-ADRDA criteria for probable AD and 55 controls were recruited from a geriatric and a psychogeriatric unit. Patients with classical musculoskeletal or neurological syndr...
OBJECTIVE Herpes simplex virus (HSV) reactivation has been identified as a possible risk factor for Alzheimer's disease (AD) and plasma amyloid-beta (Aβ) levels might be considered as possible biomarkers of the risk of AD. The aim of our study was to investigate the association between anti-HSV antibodies and plasma Aβ levels. METHODS The study sample consisted of 1222 subjects (73.9 y in mea...
Validation of cost-effective, non-invasive methods to identify early (pre-clinical) Alzheimer's disease (AD) is increasingly becoming a key research challenge. We have developed two ELISA sandwich colorimetric tests for the accurate detection of amyloid-β (Aβ)1-40 and Aβ1-42: i) directly accessible (DA) in the plasma, ii) recovered from the plasma sample (RP) after diluting the plasma sample in...
Genetic polymorphisms associated with impaired one-carbon metabolism (1-CM) can be a risk factor not only for somatic and neurological diseases, but also affective disorders (AD). Objective : to compare the frequency of genetic MTHFR, MTR, MTRR 1-CM among patients AD, their blood relatives healthy individuals. Patients methods . This cross-sectional study ( ) included AD (n=24), (n=40), as well...
An accurate and early diagnosis of Alzheimer's disease (AD) is important to select optimal patient care and is critical in current clinical trials targeting core AD neuropathological features. The past decades, much progress has been made in the development and validation of cerebrospinal fluid (CSF) biomarkers for the biochemical diagnosis of AD, including standardization and harmonization of ...
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