BACKGROUND Clinical studies have implicated preinfarct angina (brief antecedent ischemia/reperfusion [I/R]) as a predictor of more rapid thrombolysis and lower rates of reocclusion. However, the effects of antecedent ischemia on the efficacy of thrombolysis have not been rigorously assessed. Using a canine model of coronary thrombosis, we aimed to (1) reproduce these clinical findings and (2) d...

introduction:adenosine as a potent vasodilator has physiological role in regulation of regional cerebral blood flow (rcbf). metod: laser-dِoppler flowmetry technique was used to study pial vessels blood flow responses to adenosine receptors agonists and antagonist. male sprague dawley rats (250-350g) that were housed in standard conditions, were anesthetized with urethane (1.5g/kg). adenosine (g...

abstract background: the aims of this study were to assay the activity of adenosine deaminase (ada) in estrogen receptor positive (mcf-7) and negative (mda-mb468) breast cancer cell lines. methods: mda-mb468 and mcf-7 breast cancer cell lines were cultured in complete medium, striped serum with and without 0.0 1~-lm diethylstilbestrol (des), complete medium in the presence and absence of 111m t...

The effect of smoking five non-nicotine cigarettes and of breathing carbon monoxide on exercise-induced angina was evaluated in 12 patients with angina. Smoking increased venous carboxyhemoglobin from 1.71 to 5.35%, decreased exercise duration until angina 45%, increased ischemic STsegment depression at angina from 1.33 to 1.52 mm, and decreased systolic blood pressure times heart rate at angin...

Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on t...

BACKGROUND Angina is common both before and after myocardial infarction (MI). Whether the change in angina status within the first 30 days after MI is associated with subsequent readmission and angina persistence is unknown. METHODS AND RESULTS We studied 2915 MI patients enrolled at 24 hospitals in the Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction...

We investigated the prognostic significance of new-onset angina in patients in whom coronary anatomic characteristics were known. New onset angina was defined as angina of less than 3 months duration. Consecutive patients (n = 1727) with significant coronary artery disease (diagnosed at cardiac catheterization) and who had not had a prior myocardial infarction or congestive heart failure were s...

background and purpose: regarding usefulness of revascularization versus optimal medical therapy in patients with stable angina pectoris, data are challenging. the aim of this 12-month follow-up study was to compare the survival benefit associated with revascularization versus optimal medical therapy on the patients with stable angina pectoris. materials and methods: a prospective clinical stud...

The principal therapeutic approach to atherosclerotic obstructive disease is to provide a sufficient blood flow to the jeopardized area perfused by the severely narrowed or occluded artery, which is accomplished by bypass grafting surgery, percutaneous transluminal intervention, and angiogenic therapy. Angiogenesis has been clearly separated into arteriogenesis and angiogenesis in a narrow sens...

the complexes of mn(oac)3 and/or mn(acac)3 with nucleic bases and nucleosides (adenine, guanine, xanthine, adenosine and guanosine) have been synthesized in nonaqueous solution. polarographic and spectroscopic (ir and visible) methods have been used to establish the active site(s) on the imidazole and pyrimidine rings in the nucleic bases and nucleosides for the interaction with the mn(iii) com...