Purine nucleotide catabolism is common to most organisms and involves a guanine deaminase to convert guanine to xanthine in animals, invertebrates, and microorganisms. Using metabolomic analysis of mutants, we demonstrate that Arabidopsis thaliana uses an alternative catabolic route employing a highly specific guanosine deaminase (GSDA) not reported from any organism so far. The enzyme is ubiqu...

Background and Objectives: Dyslipidemia is a family of lipoprotein metabolism disorders manifested by elevated total cholesterol (TC), low-density (LDL-C), triglycerides (TG), reduced high density (HDL-C) concentrations in the blood.[1] was defined according to criteria National Cholesterol Education Program Adult Treatment Panel III. Hypercholesterolemia declared for participants with either ˃...

A multifunctional, ubiquitous molecule, adenosine acts at cell-surface G protein-coupled receptors, as well numerous enzymes, including protein kinases and adenylyl cyclase. Extracellular is thought to be produced either by export or metabolism, predominantly through ecto-5’-nucleotidase activity (also producing inorganic phosphate). It inactivated extracellular metabolism via deaminase ammonia...