Despite lingering safety concerns [1] and potential restrictions imposed by the host immune response, including the innate immune pattern recognition receptors (PRR), replicationdefective and conditionally replicating human and nonhuman adenovirus (AdV) vectors continue to be a favorite vehicle for short-term (e.g., vaccine) and long-term gene delivery. This is due in part to several desirable ...

Dendritic cells (DCs) are capable of presenting tumor-associated antigens and subsequently play an essential role in T-cell activation. The aim of this study was to develop an efficient method for gene transfer into DCs. These genetically transduced DCs can then be used as potent inducers of specific cell-mediated immune response. When compared with physical methods for gene transfer (lipofecti...