نتایج جستجو برای: adrenocortical hyperfunction

تعداد نتایج: 7010  

Journal: :The oncologist 2008
Patsy S H Soon Kerrie L McDonald Bruce G Robinson Stan B Sidhu

Adrenal tumors are common, with an estimated incidence of 7.3% in autopsy cases, while adrenocortical carcinomas (ACCs) are rare, with an estimated prevalence of 4-12 per million population. Because the prognoses for adrenocortical adenomas (ACAs) and ACCs are vastly different, it is important to be able to accurately differentiate the two tumor types. Advancement in the understanding of the pa...

2016
Kennosuke Ohashi Takeshi Hayashi Masaya Sakamoto Hiroyuki Iuchi Hirofumi Suzuki Takanori Ebisawa Katsuyoshi Tojo Hironobu Sasano Kazunori Utsunomiya

BACKGROUND Aldosterone-producing adrenocortical carcinoma is a rare malignancy, which is usually diagnosed by histopathological examination of the excised tumor. In inoperable cases, aldosterone-producing ACC diagnosed by immunohistochemical staining of the metastatic tumor for Cytochrome P450 (CYP) 11β has not previously been reported and even in that case staining for adrenocortical-specific ...

2010
Kotaro Sasaki Marisa Desimone Harsha R Rao George J Huang Raja R Seethala

Adrenocortical carcinosarcoma is an extremely rare and aggressive variant of adrenocortical carcinoma characterized by the presence of both carcinomatous and sarcomatous components, with the latter often showing heterologous differentiation. Due to the rarity and unusual histology, it may pose a diagnostic challenge. In order to increase awareness and identify potential diagnostic pitfalls, we ...

Journal: :Cancer research 1996
M Kjellman O P Kallioniemi R Karhu A Höög L O Farnebo G Auer C Larsson M Bäckdahl

The differentiation between malignant and benign adrenocortical tumors is often difficult, and better markers are required. Because the genetic background of adrenocortical tumors is poorly characterized, we used comparative genomic hybridization (CGH) to screen for DNA sequence copy number changes in 8 sporadic primary adrenocortical cancers and 14 adenomas. There was a strong relationship bet...

Journal: :Journal of Clinical Pathology 1999

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Thomas J Giordano Rork Kuick Tobias Else Paul G Gauger Michelle Vinco Juliane Bauersfeld Donita Sanders Dafydd G Thomas Gerard Doherty Gary Hammer

PURPOSE Our understanding of adrenocortical carcinoma (ACC) has improved considerably, yet many unanswered questions remain. For instance, can molecular subtypes of ACC be identified? If so, what is their underlying pathogenetic basis and do they possess clinical significance? EXPERIMENTAL DESIGN We did a whole genome gene expression study of a large cohort of adrenocortical tissues annotated...

2017
Monica Malheiros França Antonio M. Lerario Maria Candida B.V. Fragoso Claudimara Ferini Pacicco Lotfi

OBJECTIVES: Transcription Factor 21 represses steroidogenic factor 1, a nuclear receptor required for gonadal development, sex determination and the regulation of adrenogonadal steroidogenesis. The aim of this study was to investigate whether silencing or overexpression of the gene Transcription Factor 21 could modulate the gene and protein expression of steroidogenic factor 1 in adrenocortical...

2004
JOHN URQUHART

URQUHART, JOHN. Adrenal blood Juw and the adrenocortical response to corticotropin. Am. JPhysiol. 2og(6) : I 162-l 168. 1g65.-The effect of variations in adrenal blood flow on the adrenocortical response to ACTH was studied. The rate of blood flow through the perfused canine adrenal gland was a significant parameter in its response to ACTH. This effect was largest when the concentration of ACTH...

Journal: :British medical journal 1973
H Kehlet C Binder

Forty-eight patients receiving glucocorticoid treatment were tested with ACTH stimulation using alpha(1, 24) ACTH (tetracosactrin). All patients subsequently underwent non-acute major surgery without any glucocorticoid administration, and their clinical course and plasma corticosteroids were followed closely. No case of adrenocortical insufficiency was observed. A highly significant correlation...

2014
Tae Un Kim Suk Kim Jun Woo Lee Nam Kyung Lee Hong Koo Ha Won Young Park

We report a case of a 74-year-old female with myxoid adrenocortical adenoma which showed different magnetic resonance imaging findings compared to those of a typical adrenocortical adenoma. The myxoid change in the adrenocortical adenoma is a rare form of degeneration. It presents a considerable diagnostic challenge to both radiologists and clinicians because it can mimic other adrenal tumor ty...

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