OBJECTIVES To present and evaluate a new combined index of structure and function (CSFI) for staging and detecting glaucomatous damage. METHODS Observational study including 333 glaucomatous eyes (295 with perimetric glaucoma and 38 with preperimetric glaucoma) and 330 eyes of healthy subjects.All the eyes were tested with standard automated perimetry and spectral domain optical coherence tom...

PURPOSE To identify and characterize defects using the automated perimetry test in patients with primary congenital glaucoma. METHODS Automated visual fields and charts of 81 eyes (48 patients) with congenital glaucoma were retrospectively analyzed, 15 being normal eyes (group N) and 66 eyes with primary congenital glaucoma (group G). Eyes of group G were grouped in eyes without perimetric ch...

OBJECTIVE To compare performance of pointwise linear regression, Glaucoma Change Probability Analysis (GCPA), and the Advanced Glaucoma Intervention Study (AGIS) method in predicting visual field progression in glaucoma. DESIGN Longitudinal visual field data from AGIS. Proportion of progressing eyes and time to progression were the main outcome measures. One hundred fifty-six patients with 8 ...

PURPOSE To create a multivariable predictive model for glaucoma in an exclusively African American population and to compare the performance of the model with individual structural parameters derived from SD-OCT. PATIENTS AND METHODS A total of 103 healthy eyes and 118 glaucomatous eyes of African American patients underwent SD-OCT optic disc and macular scanning. Twenty-seven optic nerve hea...

objective(s):glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. glutathione s-transferases (gsts) are members of multigenic family, which have important role in cells as an antioxidant. in the present study, we examined the polymorphism of gstt1 and gstm1 deletion genotypes (t0m1, t1m0, and t0m0) in 100 glaucoma patients (41with pr...

background: glaucoma is a progressive optic neuropathy and is one of the leading causes of blindness worldwide. different factors have been contributed in the pathogenesis of glaucoma including h. pylori infection. objective: to determine the levels of anti-h. pylori igg antibody in the aqueous humor of patients with pseudoexfoliation and primary open angle glaucoma, in comparison with age and ...

In India, mutations in Cytochrome P450 (CYP1B1) are a predominant cause of not only primary congenital glaucoma (PCG) but also involved in primary open angle glaucoma (POAG) and juvenile onset glaucoma (JOAG). After ethical clearance, 100 POAG patients, 30 primary angle closure glaucoma (PACG) patients and 130 ethnically matched controls were recruited in this study. Genomic DNA was is...

BACKGROUND To determine the stage of primary open angle glaucoma at presentation at a tertiary eye unit, to assess patient's knowledge of glaucoma and acceptance and subsequent adherence to treatment. METHOD Information collected prospectively on new glaucoma patients aged 30 or more years included distance from residence and what they knew about glaucoma and its treatment. Treatment offered ...

PURPOSE The present study was conducted to examine whether the morphology of the retinal ganglion cells is altered in advanced glaucoma. Perikaryal, axonal, and dendritic alterations were monitored in glaucoma-resistant retinal ganglion cells by postvitam application of the fluorescent dye DiI. METHODS The retinas of four amaurotic glaucomatous eyes and four normal eyes enucleated after death...

BACKGROUND To stratify the outcomes of phacoemulsification combined with trabectome surgery using a new glaucoma severity index. METHODS This is a retrospective, observational cohort study that included open angle glaucoma patients with visually significant cataract that had phacoemulsification combined with trabectome surgery. Exclusion criteria were follow-up less than 12 months, any other ...