Patients taking amitriptyline (AMT) have an increased risk of sudden cardiac death, yet the mechanism for AMT's proarrhythmic effects remains incompletely understood. Here, we hypothesize that AMT activates cardiac ryanodine channels (RyR2), causing premature Ca(2+) release from the sarcoplasmic reticulum (SR), a mechanism identified by genetic studies as a cause of ventricular arrhythmias and ...

The objective of this study was to examine the psychometric properties of the Autobiographical Memory Test (AMT), which is widely used to measure overgeneral autobiographical memory in individuals with depression and a trauma history. Its factor structure and internal consistency have not been explored in a clinical sample. This study examined the psychometric properties of the AMT in a sample ...

Mass customization is implemented to provide outstanding service to customers with diverse tastes and preferences. However, mass customization has limitations in the traditional value chain and production paradigm. Taking advantage of advanced information technology, such as manufacturing grid and virtual enterprise, to facilitate mass customization and improve the customer perceived valued of ...

Microtask platforms such as Amazon Mechanical Turk (AMT) are increasingly used to create speech and language resources. AMT in particular allows researchers to quickly recruit a large number of fairly demographically diverse participants. In this study, we investigated whether AMT can be used for comparing the intelligibility of speech synthesis systems. We conducted two experiments in the lab ...

(Extended Abstract) I. INTRODUCTION Moore's Law and the market requirements for higher perfor­ mance chips are driving the production of increasingly smaller transistors, and therefore, are forcing more stringent controls on semiconductor manufacturing processes and equipment, with a very small room for error. The second trend in the semiconductor industry is the adoption of the e-Manufacturing...

Research work carried out in the last decade on the Microelectronics Manufacturing Science and Technology (MMST) program sought to address a need for increased flexibility in IC manufacturing through single-wafer processing, with in-situ sensors and real-time process/factory control has lead to a successful demonstration of a novel approach to IC manufacturing based on flexible process. To make...

A survey was carried out to determine the prevalence and appropriateness of antimicrobial therapy (AMT) in the Netherlands and to identify determinants for inappropriate AMT. Prevalence surveys of patients hospitalised in the Netherlands were performed three times in 2008 and 2009. Patients' demographic, infection-related and AMT-related data were collected from hospital wards. A total of 19 ho...

Rhesus (Rh) proteins were first identified in human erythroid cells and recently in other tissues. Like ammonia transporter (Amt) proteins, their only homologues, Rh proteins have the 12 transmembrane-spanning segments characteristic of transporters. Many think Rh and Amt proteins transport the same substrate, NH(3)/NH(4)(+), whereas others think that Rh proteins transport CO(2) and Amt protein...