Crizotinib is a standard treatment for advanced ALK-positive non-small-cell lung cancer (NSCLC). We undertook this study to investigate the pharmacokinetics of crizotinib and clinical and pharmacogenomic factors that may increase the risk of adverse events (AEs). We defined clinically significant AEs as grade 4 hematological toxicity, grade ≥3 non-hematological toxicity, and any grade of inters...

in order to study the effects of climate and geomorphology on the development of soils and their physico-chemical peroperties, two transects on the loess parent material were selected in two regions of golestanprovince. the regions were: huttan (maraveh tappeh area) and gorgan with aridic-thermic and xeric-thermic soil moisture and temperature regimes, respectively. four pedons in hutan and fiv...

AES is probably the most widely studied and used block cipher. Also versions with a reduced number of rounds are used as a building block in many cryptographic schemes, e.g. several candidates of the CAESAR competition are based on it. So far, non-random properties which are independent of the secret key are known for up to 4 rounds of AES. These include differential, impossible differential, a...

Magnetic activated carbon particles (Fe3O4/active composites) as auxiliary electrodes (AEs) were fixed on the surface of Ti/Sb-SnO2 foil by a NdFeB magnet to form new magnetically assembled electrode (MAE). Characterizations including cyclic voltammetry, Tafel analysis, and electrochemical impedance spectroscopy carried out. The oxidation performances MAE towards different simulated wastewaters...

On January 8th 2003, Eric Filiol published on eprint.iacr.org a paper [11] in which he claims that AES can be broken by a very simple and very fast ciphertext-only attack. If such an attack existed, it would be the biggest discovery in code-breaking since some 10 or more years. Unfortunately the result is very hard to believe. In this paper we present the results of computer simulations done by...

The interaction of borazine (NsB,H,) with a Re(0001) surface has been studied by low energy electron diffraction (LEED), thermal desorption spectroscopy (TDS), Auger electron spectroscopy (AES) and electron energy loss spectroscopy (ELS). Two LEED patterns have been observed following borazine adsorption and annealing. One is the 2 X 2 structure, assigned to arise from atomic nitrogen. The othe...

The interaction of nitrogen with a Re(OOO1) surface has been studied by low energy electron diffraction (LEED), thermal desorption spectroscopy (TDS), Auger electron spectroscopy (AES) and electron energy loss spectroscopy (ELS). Two LEED patterns have been observed upon adsorption of nitrogen on Re(OOO1). One, identified as the 4 x 1, is induced by N, exposure at 115 K and is related to the or...

this paper mainly focused on implementation of aes encryption and decryption standard aes-128. all the transformations of both encryption and decryption are simulated using an iterativedesign approach in order to minimize the hardware consumption. this method can make it avery low-complex architecture, especially in saving the hardware resource in implementing theaes inversesub bytes module and...