BACKGROUND A degradation study of aflatoxin B1 (AFB1) was carried out using a combination of physical and chemical methods. AFB1 was heated at 80 °C in the presence of acetic, citric and lactic acids for various time periods. The cytotoxicity of the degraded AFB1 and its products were determined by MTT assay. RESULTS The results showed that among the three organic acids lactic acid was most e...

Exposure to aflatoxins causes liver fibrosis and hepatocellular carcinoma posing a significant health risk for human populations and livestock. To understand the mammalian systems responses to aflatoxin-B1 (AFB1) exposure, we analyzed the AFB1-induced metabonomic changes in multiple biological matrices (plasma, urine, and liver) of rats using (1)H NMR spectroscopy together with clinical biochem...

A total of 65 maize grain samples , from 7 maize producing areas of Pakistan, were assayed for 14 toxicologically significant mycotoxins viz., aflatoxin B1 (AfB1), aflatoxin B2 (AfB2), aflatoxin G1 (AfG1), aflatoxin G2 (AfG2), zearalenone (ZON), deoxynivalenol (DON), 3acetyl-deoxynivalenol (3A-DON), 15acetyl-deoxynivalenol (15A-DON), nivalenol (NIV), T-2 toxin (T-2), HT-2 toxin (HT-2), diacetox...

The objectives of this study were: 1) to examine effects of a dietary sodium bentonite, ASTRABEN–20 (AB20) [Prince Agri Products, Inc., Quincy, Ill.], on in vitro binding of T2 toxin and aflatoxin B (AFB1); ® 1 and 2) to examine the effects of AB20 in broiler chicks fed 6 ppm dietary T2 toxin (T2) or 4 ppm aflatoxin B1 (AFB1) to 21 d. Day-old male broiler chicks were randomly placed in batterie...

Aflatoxin B1 (AFB1) is a fungal toxin that has been associated with primary hepatocellular carcinoma (HCC) in humans. This study was undertaken to determine the cellular and molecular mechanisms by which the antioxidants b-carotene and lycopene inhibit AFB1-induced toxic changes in human hepatocytes (HepG2 cells). An in vitro system was optimized to test the chemoprotective effects of lycopene ...

Aflatoxin B1 (AFB1) is a highly toxic and carcinogenic metabolite produced by Aspergillus species on food and agricultural commodities. Inhibitory effects of essential oils of Ageratum conyzoides (mentrasto) and Origanum vulgare (oregano) on the mycelial growth and aflatoxin B1 production by Aspergillus flavus have been studied previously in culture medium. The aim of this study was to evaluate...

Objective The number of deaths from heart disease is increasing worldwide. Aflatoxin B1 (AFB1), a toxin produced by the fungi Aspergillus flavus and Aspergillus parasiticus, is frequently detected in improperly processed/stored human food products. While AFB1 hepatotoxicity and carcinogenic properties have been well addressed, its myocardial toxicity is poorly documented. This study aimed to in...

Dietary exposure to aflatoxin B1 (AFB1) is detrimental to avian health and leads to major economic losses for the poultry industry. AFB1 is especially hepatotoxic in domestic turkeys (Meleagris gallopavo), since these birds are unable to detoxify AFB1 by glutathione-conjugation. The impacts of AFB1 on the turkey hepatic transcriptome and the potential protection from pretreatment with a Lactoba...

Aflatoxin B1 (AFB1) is a contaminant of grain and fruit and has one of the highest levels of carcinogenicity of any natural toxin. AFB1 and the fungi that produce it can also contaminate the raw materials used for beer and wine manufacture, such as corn and grapes. Therefore, brewers must ensure strict monitoring to reduce the risk of contamination. In this study, the fate of AFB1 during the fe...

this study was conducted to investigate the effect of aflatoxin b1 (afb1) on performance and egg quality in broiler breeders and the abatement of its deteriorative effect through its counteraction with herbal mycotoxin binder (hmb). thirty-six, 28-wk-old broiler breeder hens were allotted to one of the three treatments of: (1) basal diet (control),(2) control plus 500 μg kg-1 afb1 and (3) contr...