نتایج جستجو برای: airway clearance
تعداد نتایج: 130511 فیلتر نتایج به سال:
ABSTRACT There has been remarkable progress in the treatment of cystic fibrosis (CF) patients over the past 20 years. However, limitations of standard therapies have highlighted the need for a convenient alternative treatment to effectively target the pathophysiologic basis of CF-related disease by improving mucociliary clearance of airway secretions and consequently improve lung function and r...
Mucociliary clearance is essential to the defense mechanisms of the respiratory system. Loss of normal mucociliary clearance contributes to the pathogenesis of genetic and acquired lung diseases. Treatment of cultured differentiated human airway epithelial tissue with IL-13 resulted in a loss of ciliated epithelial cells and an increase in mucus-secreting cells. The loss of ciliated cells was c...
Hyperosmolarity of the airway surface liquid (ASL) has been proposed as the stimulus for hyperpnoea-induced asthma. We found previously that mucociliary clearance (MCC) was increased after isocapnic hyperventilation (ISH) with dry air, and we proposed that the increase related to transient hyperosmolarity of the ASL. We investigated the effect of increasing the osmolarity of the ASL on MCC, by ...
Questions: In adults with an acute exacerbation of chronic obstructive pulmonary disease (COPD) receiving non-invasive positive pressure ventilation (NIV), is intrapulmonary percussive ventilation (IPV) feasible? Does IPV improve outcomes compared to manual airway clearance techniques? Design: Randomised, controlled trial with concealed allocation. Setting: Intensive care unit of a tertiary hos...
Questions: In adults with an acute exacerbation of chronic obstructive pulmonary disease (COPD) receiving non-invasive positive pressure ventilation (NIV), is intrapulmonary percussive ventilation (IPV) feasible? Does IPV improve outcomes compared to manual airway clearance techniques? Design: Randomised, controlled trial with concealed allocation. Setting: Intensive care unit of a tertiary hos...
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