Chronic liver disease is known to cause several skin manifestations, including cutaneous vascular changes such as palmar erythema and spider angioma. Spider angioma has been reported to be associated with severe chronic liver disease [1]. A 54-year-old male patient presented herein had diagnosed alcoholic cirrhosis for ten years and upper gastrointestinal endoscopy revealed grade III esophageal...

Liver Disease-Bouchier et al. MEDICAL JOURNAL gamma-globulin and that, in liver disease, the antibody is frequently a macroglobulin, while in D.L.E. it is predominantly a 7S gamma-globulin (Weir and Holborow, 1962). Positive A.N.F. tests were found in the absence of a positive L. Mackay and Wood, 1962). Unlike Calabresi and Greenberg's (1960) findings, antinuclear antibodies were not found in t...

BACKGROUND Significantly higher prevalence of Strongyloides stercoralis has been reported in chronic alcoholic patients. The aim of this investigation was to report the prevalence of Strongyloides larvae in stools of chronic alcoholic patients with known daily ethanol intake. METHODS From January 2001 through December 2003 the results of fecal examinations and the daily ethanol intake were re...

The zinc content of peripheral blood leucocytes has been measured in normal controls and in three groups of patients with liver disease. A significant reduction in leucocyte zinc, but not erythrocyte zinc, was observed in patients with primary biliary cirrhosis, alcoholic cirrhosis, and active chronic hepatitis. It is suggested that the nucleated tissues of some patients with liver disease are ...

In Japan, preventive measures for hepatocellular carcinoma are urgently required, because the prevalence of this neoplasm and associated mortality have been increasing (Takada et al., 1994). It is clear that most non-viral cases of hepatocellular carcinoma arise with a background of alcoholic liver cirrhosis and that the incidence of hepatocellular carcinoma is higher in heavy drinkers than in ...

1. Mitochondria and microsomal fractions have been isolated from liver biopsies from patients with alcoholic cirrhosis, cryptogenic cirrhosis or chronic aggressive hepatitis. 2. Cirrhotic livers yieled fewer mitochondria than normal liver. 3. The most significant change was a decrease in mitochondrial respiratory control. Cirrhotic microsomal fractions had a 50% diminution in cytochrome b5 and ...

CONTEXT In about 10% of patients with chronic liver disease, it is not possible to identify an etiologic factor. These cases are called cryptogenic cirrhosis. Currently, nonalcoholic steatohepatitis (NASH) is being considered as a possible etiologic factor for a significant segment of patients that presents with cryptogenic cirrhosis. OBJECTIVE To estimate the prevalence of risk factors for N...

Alcohol use disorders and alcohol dependency affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Alcoholic liver disease is caused by acute and chronic exposure to ethanol which promotes oxidative stress and inflammatory response. Chronic consumption of ethanol implies liver steatosis, which is the first morphological change in the...

Excessive alcohol consumption is a global healthcare problem. The liver sustains the greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol metabolism. Chronic and excessive alcohol consumption produces a wide spectrum of hepatic lesions, the most characteristic of which are steatosis, hepatitis, and fibrosis/cirrhosis. Steatosis is the earliest response to...

BACKGROUND The Dionysos Study is a cohort study of the prevalence of chronic liver disease in the general population of two northern Italian communities. It included 6917 subjects, aged 12-65 (69% of the total population). AIMS The aim of this part of the study was to examine the relationship of daily alcohol intake, type of alcoholic beverage consumed, and drinking patterns to the presence o...