Hollow polyphosphazene microcapsules have been fabricated by the covalent layer-by-layer assembly of polydichlorophosphazene (PDCP) and hexamethylenediamine (HDA) on aminosilanized silica particles, followed by core removal in a HF/NH(4) F solution. The hollow and intact microcapsules in both wet and dry states have been characterized by transmission electron microscopy and confocal laser scann...

Biologically triggered exploding microcapsules were synthesized by layer-by-layer assembly of biopolymers. The microcapsules showed controlled rupturing behaviour upon exposure to a pathologically relevant biomolecule, trypsin. These microcapsules offer significant potential for clinical applications.

Microencapsulation of plant-beneficial bacteria for use as biopesticides is a growing area interest in the search alternatives to harmful chemical pesticides. In this study, we assessed microencapsulation Gram-negative, non-spore-forming bacterial strain Collimonas arenae Cal35 novel cross-linked alginate microcapsules (CLAMs) formed by spray-drying, and matrix shell (CLAMshell) particles fluid...

The encapsulation of cells into polymeric microspheres or microcapsules has permitted the transplantation of cells into human and animal subjects without the need for immunosuppressants. Cell-based therapies use donor cells to provide sustained release of a therapeutic product, such as insulin, and have shown promise in treating a variety of diseases. Immunoisolation of these cells via microenc...

Host response to implanted biomaterials and medical devices poses tremendous challenges to their clinical applications. Today, the quest to mitigate this immunological attack for improved longevity of these devices remains daunting. This thesis aims to explore the use of anti-inflammatory drugs in minimizing the host response and improve the efficacy of implantable and transplantable therapeuti...

Polyurea microcapsules containing 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide as the active agent were prepared by the method of interfacial polycondensation with methylene bis(phenyl isocyanate) as the multifunctional isocyanate, hexamethylene diamine as the diamine, and anionic sodium lignin sulphonate as the emulsifying agent . Thermal stability of the microcapsules was investi...

In this work, 1.4 mm dibutylphthalate (DBP) filled urea–formaldehyde (UF) microcapsules were used as Pickering stabilizers to create larger 140 mm microcapsules containing a second liquid phase, dicyclopentadiene (DCPD). The binary microcapsules were made by encapsulating the dispersed DCPD liquid (stabilized with the UF(DBP) microcapsules in water) via an isocyanate–alcohol interfacial polymer...

Here we describe the preparation of BSA-FITC-loaded microcapsules as a model protein system for in vivo delivery. BSA-FITC-loaded microcapsules were prepared using a mono-axial nozzle ultrasonic atomizer, varying a number of parameters to determine optimal conditions. The preparation method chosen resulted in a BSA-FITC encapsulation efficiency of approximately 60% and a particle size of approx...