introduction: insertion or deletion of a guanine in -1607 at promoter region of matrix metalloproteinase-1 enzyme creates two allelic types for this gene in the population: 2g and 1g, respectively. 2g allele contains an extra binding site for ets transcription factors that this may increase the level of gene expression. therefore, aim of this study was investigation of the single guanine insert...

The aim of the present study was to evaluate genotypic distribution calpastatin (CAST) and insulin-like growth factor 1 (IGF1) gene polymorphisms in Tsigai sheep breed. Genomic DNA isolated from blood samples by phenol-chloroform method. A total 56 were genotyped PCR-RFLP Allele genotype frequencies calculated standard procedures. To population-genetic properties, Hardy–Weinberg Equilibrium (HW...

The current study examined the relationship between renal cell carcinoma-related risk and gene polymorphisms in interleukin-10, vitamin D receptor cytochrome P450 1A1 genes. Using preferred reporting items for systematic reviews meta-analyses criteria, link carcinoma was studied by utilizing Web of Science, Embase, PubMed Wanfang databases. CC TT genotypes along with interleukin-10-819C/T C-all...

Summary Recently, allele-specific single-cell RNA-seq analysis has demonstrated widespread dynamic random monoallelic expression of autosomal genes (aRME) in different cell types. However, the prevalence aRME during pregastrulation remains unknown. Here, we show that is lineages embryos. Additionally, origin elusive. It believed independent transcriptional bursting from each allele lea...

HE gene A , in maize was first reported, with its mutant allele a,, by EMERSON (1918, 1921). In these reports and later publications by EMERSON and ANDERSON (1932) and LAUGHNAN (1948) the A , allele found in North American races was shown to be necessary for the production of anthocyanin pigments in various tissues of the corn plant. With the complementary genes A,, B, Pl, and R' or r', A , pro...

Pachyonychia congenita (PC) is a rare skin disease that inherited in an autosomal dominant pattern. PC associated with mutations the genes encoding keratins K6, K16 or K17, which are related to epidermal hyperproliferation. patients experience severe and painful palmoplantar keratoderma accompanied by blistering highly disabling as it greatly impairs ambulation. No curative treatment currently ...

Pemphigus vulgaris (PV) is an acquired autoimmune blistering disease characterized by the production of autoantibodies targeting desmosomal cadherins, primarily desmoglein 1 and 3, leading to acantholysis. The etiology PV multifactorial, including genetic susceptibility. This retrospective study aimed evaluate association HLA class II alleles examine impact PV-associated on concentration anti-d...

In Table 1, the allele ratio in column eight (Allele Ratios b : Cases, Controls) refers to allele A: allele B and not allele1:allele2 as described in footnote b, with Allele A being the Susceptibility Allele as denoted in column seven. The footnote should read: b Number of alleles were compared in cases versus controls: allele A: allele B cases, allele A: allele B controls. Allele A refers to t...