Stem cell strategies focused on replacement of RPE cells for the treatment of geographic atrophy are under intense investigation. Although the eye has long been considered immune privileged, there is limited information about the immune response to transplanted cells in the subretinal space of large animals. The purpose of this study was to evaluate the survival of allogenic induced pluripotent...

PURPOSE The purpose of this case series was to evaluate the effect of guided bone regeneration using demineralized allogenic bone matrix with calcium sulfate. MATERIALS AND METHODS Guided bone regeneration using Demineralized Allogenic Bone Matrix with Calcium Sulfate (AlloMatrix™, Wright. USA) was performed at the time of implant placement from February 2010 to April 2010. At the time of the...

Calcaneocuboid distraction arthrodesis is regarded as an excellent and reliable surgical procedure for correction of pes planovalgus. Despite a potentially high complication rate, the use of an autologous iliac crest graft is regarded as the method of choice. In a prospective trial the results in 12 feet after calcaneocuboid distraction arthrodesis for pes planovalgus correction with allogenic ...

Purpose. To compare the costs of femoral head banking versus bone substitutes. Methods. Records of femoral head banking from 1998 to 2008 were reviewed. The cost of allogenic cancellous bone graft was calculated by estimating the direct expenditure of femoral head procurement, screening tests, and storage, and then divided by the amount of bone harvested. Results. 326 females and 141 males (mea...

Background Experimental studies suggest that mechanical cell washing to remove pro-inflammatory components that accumulate in the supernatant of stored donor red blood cells (RBCs) might reduce inflammation and organ injury in transfused patients. Methods Cardiac surgery patients at increased risk of large-volume RBC transfusion were eligible. Participants were randomized to receive either me...

Biomaterials, including non-biodegradable and biodegradable polymers, and collagen and fibrin matrices, have been used in experimental and clinical arterial reconstruction. While these biomaterials exhibit various characteristics suitable for arterial reconstruction, the patency of biomaterial-based arterial substitutes remains problematic because of inflammation and thrombogenesis. Endothelial...

There is wide variation in the management of coagulation and blood transfusion practice in liver transplantation. The use of blood products intraoperatively is declining and transfusion free transplantations take place ever more frequently. Allogenic blood products have been shown to increase morbidity and mortality. Primary haemostasis, coagulation and fibrinolysis are altered by liver disease...

Allogenic bone marrow transplantation (BMT) is a curative therapy for malignant and nonmalignant lymphohematopoietic diseases and other disorders. However, the development of secondary malignancies is an important complication among transplantation survivors. Patients who have undergone BMT have a 2to 8-fold higher risk of developing these cancers than the general population. After BMT, the mos...

The use of deposited autologous blood instead of allogenic blood is recommended in cases of elective maxillofacial operations if the blood transfusion probability is more than 10%. As an alternative, the controlled intraoperative normovolemic hemodilution and the preoperative use of EPO (Erytropoetin) should be considered. In a retrospective study, we analyzed 438 patients who underwent orthogn...

Interleukin-10 (IL-10) plays an indispensable role in mucosal tolerance by programming dendritic cells (DCs) to induce suppressor Th-cells. We have tested the modulating effect of L. lactis secreting human IL-10 (L.  lactis(IL-10)) on DC function in vitro. Monocyte-derived DC incubated with L.  lactis(IL-10) induced effector Th-cells that markedly suppressed the proliferation of allogenic Th-ce...