Assessments made over the past few decades have suggested that boreal forests may act as a sink for atmospheric carbon dioxide. However, the fate of the newly accumulated carbon in the living forest biomass is not well understood, and the estimates of carbon sinks vary greatly from one assessment to another. Analysis of remote sensing data has indicated that the carbon sinks in the Russian fore...

The mammary gland goes through a coordinated series of developmental states during postnatal life in preparation for lactation. These changes ultimately reflect a changing endocrine environment alongside local alterations in the microenvironment. A longstanding assumption has been that estrogens serve as the first essential component for any of these developmental changes to be realized in the ...

The aim was to investigate interspecies relationships between body weight (W) (kg) and various pharmacokinetic parameters for the anti-tumor agents amsacrine and its 4-methyl-5-(N-methylcarboxamide) analogue, CI-921, and examine which pharmacokinetic parameter, if any, might be used to predict the toxicity of these agents. Pharmacokinetic, plasma protein binding, and toxicity data were availabl...

Cognitive abilities rise steeply from infancy to young adulthood and then are either maintained or decline to old age, depending on the specific ability. This pattern suggests corresponding continuities of mechanism and process, but it is striking that the fields of cognitive development and cognitive aging make little contact with each other's methods and theories. In this review we examine re...

TO THE EDITOR—We thank Dr Pai for highlighting the importance of optimal dosing of polymyxins [1]. As described in our original paper [2], a number of commonly used approaches to account for body size were extensively evaluated via population modeling and covariate analysis. These body size models included allometric and linear scaling by both total body weight (TBW) and lean body weight (LBW),...

We studied the developmental trends of temperament and character in a longitudinal population-based sample of Finnish men and women aged 20-45 years using the Temperament and Character Inventory model of personality. Personality was assessed in 1997, 2001, and 2007 (n = 2,104, 2,095, and 2,056, respectively). Mean-level changes demonstrated qualitatively distinct developmental patterns for char...

We describe gene-environment processes that may help account for individual differences in successful aging. Our emphasis is on successful aging in the cognitive domain, wherein individuals come to use a variety of strategies to cope with changes in cognitive capacities. We focus on the role of executive control in particular and define gene-environment correlation and nonshared environmental m...

Personality has been implicated in romantic and sexual relationships, but its association with childbearing is poorly understood. The authors assessed whether 3 personality traits--sociability, emotionality, and activity--predicted the probability of having children and whether having children predicted personality change. The participants were women and men from the Cardiovascular Risk in Youn...