GRAY, SARAH, D., AND NORMAN C. STAUB. Resistance to bloodJEow in leg muscles of dog during tetanic isometric contraction. Am. J. Physiol. 213(3): 677-682. 1967.~We have reinvestigated the effects of tetanic, isometric leg muscle contraction in anesthetized dogs on the resistance to blood flow. In 19 of 20 dogs vascular resistance increased during the contraction. There appear to be two phases o...

Electrical stimulation has been used to prevent muscle atrophy, but this method is different in many previous studies, appropriate stimulation protocol is still not decided. Although resistance exercise has also been shown to be an effective countermeasure on muscle atrophy, almost previous studies carried out an electrical stimulation without resistance. It was hypothesized that electrical sti...

The study investigated the effect of methanol extract and its fractionations obtained from Yemeni khat on the smooth muscle isometric tension in Lewis rat aortal ring preparations and compared the effects of the crimson and green leaves. Khat leaves were sorted into green (khat Light; KL) and crimson (khat Dark; KD) leaves, extracted with methanol, followed with solvent-solvent extraction (benz...

Morphine inhibits small intestinal transit in mice, although few mu-opioid receptors are present in the ileum. The present study focused on the action of morphine in the isolated mouse ileum to reveal the mechanism by which morphine inhibits mouse small intestinal transit. In the isolated circular muscle, morphine caused tonic contraction. This contraction was potently inhibited by naloxone and...

The mechanism of action of MD1, a new biotechnological radiotherapeutic agent of plant origin, on smooth muscle contraction was investigated. Contraction induced by MD1 consists of an initial dose-dependent transient phasic response (PR) (with ED50 = 0.11 +/- 0.02%, n = 4, the time of rise 15 s, onset of decay about 30 s) followed by a tonic contraction (TC) (at 10% MD1 only) with a maximum in ...

We study the L 2 -type contraction property of large perturbations around shock waves scalar viscous conservation laws with strictly convex fluxes in one space dimension. The holds up to a shift, and it is measured by weighted relative entropy, for which we choose an appropriate entropy associated flux. In particular, handle shocks small amplitude. This result improves recent article [19] autho...

Acetylstrophanthidin, 0.3 to 10 /xg/ml, caused contraction of helical strips of the dog cutaneous vein in an organ bath at 37°C. A latent period of 12 to 60 minutes preceded the contraction. During this time, the vein exhibited a progressive increase in response to transmural electric stimulation and added norepinephrine. As the dose of acetylstrophanthidin was increased, the latent period shor...

Cicatricial contraction of preretinal fibrous membrane is a cause of severe vision loss in proliferative vitreoretinal diseases such as proliferative diabetic retinopathy (PDR) and proliferative vitreoretinopathy (PVR). TGF-beta is overexpressed in the vitreous of patients with proliferative vitreoretinal diseases and is also detectable in the contractile membranes. Therefore, TGF-beta is presu...

Loading of extracted muscle fibers causes a small, sudden lengthening, followed by a slower, plastic extension, which is reversed only by active contraction. Polyphosphates in the presence of Mg strongly accelerate plastic extension, but elastic changes in length remain the same as during rigor. The modulus of elasticity on the average is about 6.2 x 10(7) dynes per cm.(2) This value is about 4...