A 13 year old girl presented with auricular chondritis and recurrent episodes of unexplained chest pain, arthritis, bronchitis, conjunctivitis, prolonged steroid resistant alopecia areata, and a history of recurrent tonsillitis. Both the mosaic of autoimmunity and relapsing polychondritis were considered in the differential diagnosis. The patient was successfully treated with co-trimoxazole. Th...

Localized scalp hair loss has different causes which alopecia areata, trichotillomania, tinea capitis and early lupus erythematosus are the most important ones. There are several reports of localized alopecia after tick and flea bites and bee stings, but there is only one report of ant-induced alopecia in the literature. We report herein two cases of alopecia induced by ants of genus Phei...

Background: Alopecia areata has a wide range of different clinical presentations. It may present as localized or diffuse hair thinness without hair loss, a small patch of hair loss or may progress to alopecia totalis and universalis. Objectives: Determination of clinical patterns of alopecia areata in Kerman province and to compare the results with other studies in other countries. Patients and...

Three siblings with infantile-onset biotin-responsive multiple carboxylase deficiency are described. Recognition of the characteristic dermatologic manifestations, alopecia and periorificial dermatitis, should result in early diagnosis and institution of potentially lifesaving therapy with biotin. Other metabolic disorders may present a similar clinical picture. Immunologic dysfunction and/or a...

The microcystic adnexal carcinoma is a rare, locally aggressive malignant adnexal neoplasm associated with significant morbidity. It is often underdiagnosed due to clinical and histopathological resemblance with other cutaneous neoplasms and/or a combination of lack of familiarity associated with inadequate samples. We report a case with clinical hypothesis of scarring alopecia and histopatholo...

We describe a young woman with primary adrenal insufficiency, hypoparathyroidism (autoimmune polyglandular syndrome type 1), Graves disease, vitiligo, and alopecia universalis. Five years after the diagnosis, she presented with recurrent ophthalmological and neurological disorders as features of Vogt-Koyanagi-Harada syndrome. A marked therapeutic response was noted on systemic high-dose cortico...

Cronkhite-Canada syndrome is a rare disease characterised by diffuse polyposis of the gastrointestinal tract, diarrhoea, weight loss, abdominal pain, cutaneous hyperpigmentation, dystrophic changes of fingernails, and alopecia. The etiology is probably autoimmune and diagnosis is based on history, physical examination, endoscopic findings of gastrointestinal polyposis, and histology. The diseas...

BACKGROUND Alopecia is one of the most important hair follicle (HF) disorders, which is divided into scarring (cicatricial) and nonscarring (noncicatricial) types. OBJECTIVE The aim of this study is to investigate the expression of stem cell (SC) markers such as cytokeratin (CK) 17 and CK19 in scarring and nonscarring alopecia. MATERIALS AND METHODS Thirty patients with scalp alopecia (15 w...

Autoimmune polyendocrinopathy type II is rarely reported in Chinese patients. A 42-year-old Chinese woman with a history of Hashimoto's thyroiditis and hypogonadotropic hypogonadism presented with pneumonia. During hospitalisation, she went into an adrenal crisis and diabetic ketoacidosis. Subsequent dynamic hormonal tests revealed primary and secondary adrenal insufficiency. She also had perni...

Hair follicles are complex skin appendages, the perturbations of which have an impact on human health and emotional welfare disproportionate to their small dimensions. Changes to the parameters of hair follicle size, numbers per unit area of skin, and growth cycle time duration determine hair coverage and fundamentally underlie the diagnosis of an individual with alopecia or hypertrichosis. Her...