Avian leukosis virus induces tumors in chickens by integrating into the genome and altering expression of nearby genes. Thus, ALV can be used as an insertional mutagenesis tool to identify novel genes involved in tumorigenesis. Deep sequencing analysis of viral integration sites has identified CTDSPL and CTDSPL2 as common integration sites in ALV-induced B-cell lymphomas, suggesting a potential...

Objective. To assess the frequency and degree of bacterial contamination respiratory tract in patients cardiac surgery hospital, who are on prolonged mechanical ventilation, to evaluate efficiency sanitation oral cavity with a solution chlorhexidine.
 Materials methods. A comparative analysis tracheobronchial microbiota operated hospital undergoing (4872 hours) artificial lung ventilation ...

The absence or deficiency of DNA mismatch repair (MMR) activity results in microsatellite instability (MSI) in cancer. The avian leukosis virus (ALV) causes neoplastic disease in chickens. In this study, the status of MMR, MSI, the cell cycle and apoptosis were detected in DF-1 cells after avian leukosis virus subgroup A infection. Flow cytometry analysis results indicated that there was no sig...

Formalin-fixed suspect tumors were submitted to the Poultry Diagnostic and Research Center at the University of Georgia (Athens, GA) for diagnosis. Samples were from fancy breed chickens with a history of increased tumor prevalence in both hens and roosters. Microscopically, in all the samples, there were neoplastic proliferations of spindle-shaped cells. The matrix surrounding tumor cells stai...

To date, the vast majority of known virus-encoded microRNAs (miRNAs) are derived from polymerase II transcripts encoded by DNA viruses. A recent demonstration that the bovine leukemia virus, a retrovirus, uses RNA polymerase III to directly transcribe the pre-miRNA hairpins to generate viral miRNAs further supports the common notion that the canonical pathway of miRNA biogenesis does not exist ...

Avian leukosis virus is recognized as an important viral pathogen in the poultry industry, resulting salient severe economic losses due to reduced production, uneven flock growth rates, growth, and immunosuppression which predispose affected birds other infections. This study examined seroprevalence of avian (ALV) local chickens (LC) 5 different live bird markets (LBMs) Kaduna Metropolis. A tot...