نتایج جستجو برای: alzheimer disease ad
تعداد نتایج: 1556084 فیلتر نتایج به سال:
a b s t r a c t alzheimer's disease (ad) is a neurodegenerative disorder in geriatric people that characterized by reduction in memory and learning ability. attenuation of cholinergic system is the most likely hypothesis. therefore, potentiation of the cholinergic system via inhibition of acetylcholinesterase enzyme could improve and alleviate the symptoms of ad. a new series of isatin-based ...
Alzheimer disease (AD) is characterized by numerous senile plaques (SP) in addition to widespread neocortical neurofibrillary tangles (NFT). Some elderly have pathologic aging (PA), which is characterized by numerous SP composed of diffuse amyloid deposits with few or no NFT confined to the limbic lobe. Both AD and PA represent a range of Alzheimer type pathology (ATP). Some cases of progressiv...
OBJECTIVE To identify plasma biomarkers for the diagnosis of Alzheimer disease (AD). DESIGN Baseline plasma screening of 151 multiplexed analytes combined with targeted biomarker and clinical pathology data. SETTING General community-based, prospective, longitudinal study of aging. PARTICIPANTS A total of 754 healthy individuals serving as controls and 207 participants with AD from the Au...
• PREVENT-AD is openly releasing datasets to the neuroscience community. a longitudinal study of older adults at-risk Alzheimer disease. Data include imaging, genetics, fluid biochemistry, neurosensory, cognition and more. collection methods data sharing plans for open science are described. To move Disease (AD) research forward it essential collect from large cohorts, but also make such availa...
Alzheimer disease (AD)-related pathology was assessed in cortical biopsy samples of 111 patients with idiopathic normal-pressure hydrocephalus. Alzheimer disease hallmark lesions-β-amyloid (Aβ) and hyperphosphorylated tau (HPtau)-were observed in 47% of subjects, a percentage consistent with that for whole-brain assessment reported postmortem in unselected cohorts. Higher-immunostained area fra...
Early accurate detection of Alzheimer disease (AD) and its prognostic stage, i.e., Mild Cognitive Impairment (MCI) is getting more and more vital. A novel approach is applied for the diagnosis of very mild (CDR0.5) to mild (CDR-1) Alzheimer disease patients from normal controls combining morphometric features along with MMSE (Mini Mental State Examination) score. The combined features are fed i...
OBJECTIVES To determine the genetic contribution to non-autosomal dominant early-onset Alzheimer disease (EOAD) (onset age ≤60 years) cases and identify the likely mechanism of inheritance in those cases. DESIGN A liability threshold model of disease was used to estimate heritability of EOAD and late-onset Alzheimer disease (AD) using concordance for AD among parent-offspring pairs. SETTING...
background and objectives: alzheimer's disease (ad) as a neurodegenerative disorder is the most common form of dementia in the elderly. according to the amyloid hypothesis, accumulation of amyloid beta (aβ) plaques, which are mostly constituted of aβ peptide aggregates, triggers pathological cascades that lead to neuronal cell death. thus, modulation of aβ toxicity is the hopeful therapeut...
BACKGROUND Prevalences of Alzheimer disease (AD) and vascular dementia (VaD) in China reportedly differ from those in Western countries. OBJECTIVE To estimate prevalence of AD and VaD in 4 regions of China. DESIGN Cross-sectional, population-based prevalence survey with a stratified, multistage cluster sampling design. SETTING Rural (n = 99) and urbanized (n = 71) communities of Beijing, ...
Melatonin secretion decreases in Alzheimer´s disease (AD) and this decrease has been postulated as responsible for the circadian disorganization, decrease in sleep efficiency and impaired cognitive function seen in those patients. Half of severely ill AD patients develop chronobiological day-night rhythm disturbances like an agitated behavior during the evening hours (so-called "sundowning"). M...
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