“older people are an enormous asset to our societies, not only because a large majority of them continue to work in old age, but also because they convey social values to younger generations” dr. wesum asia/pacific regional conference on ageing 2012 the population ages 65 and over is expected to grow very rapidly in all parts of the world. over the next decades, the elderly population is projec...

objective(s) the present study aimed to investigate the effects of a fat soluble antioxidant, coenzyme q10 (coq10) and folic acid on learning and memory in the rats with intracerebroventricular injection of streptozotocin (icv-stz), an animal model of sporadic type of alzheimer's disease. materials and methods the lesion groups were injected bilaterally with icv-stz (1.5 mg/kg b.wt., in no...

objective(s):alzheimer's disease (ad) is the most common age-related neurodegenerative disorder. one of the hallmarks of ad is an abnormal accumulation of fibril forms of tau protein which is known as a microtubule associated protein. in this regard, inhibition of tau aggregation has been documented to be a potent therapeutic approach in ad and tauopathies. unfortunately, the available syn...

introduction: estrogen is one of the gonadal hormones that has multiple beneficial actions in central nervous system and involves in learning and memory. alzheimer's disease (ad) is a progressive neurodegenerative disorder that impairs patient memory. the human nucleus basalis of meynert (nbm) is severely affected in alzheimer's disease. so in this study the effect of peripheral (intr...

background and objectives:traditional medicine is an important approach to achieve new therapeutic strategies in basic and clinical pharmacology. allium hirtifolium boiss. and astragalus hamosus l. have been mentioned in iranian traditional medicine references for a kind of dementia with features and symptoms similar to those of alzheimer's disease (ad). in the present study, the neuroprot...

conclusions these data suggest that single bilateral microinjection of aβ (25-35) could impair memory and can be used as an ad model in wistar rats. results the results showed that aβ (25-35) significantly impaired both step-through latency and time in dark compartment in the passive avoidance task. background alzheimer's disease (ad) is the most common form of dementia that leads to neurotoxic...

different treatment strategies of alzheimer's disease (ad) are being studied for treating or slowing the progression of ad. many pharmaceutically important regulation systems operate through proteins as drug targets. here, we investigate the drug target proteins in beta-amyloid (aβ) injected rat hippocampus treated with lavandula angustifolia (la) by proteomics techniques. the reported stu...

alzheimer’s disease (ad) is a progressive neurodegenerative disorder that affects regions of the brain that control cognition, memory, language, speech and awareness to one’s physical surroundings. the pathological initiation and progression of ad is highly complex and its prevalence is on the rise. in his study, alzheimer's disease was induced with single injection of amyloid-β (aβ) pepti...

Surface-enhanced Raman scattering (SERS), owing to its high sensitivity based on localized surface plasmon resonance of nanostructured metals, is recently attracting much attention be used for biotechnology, such as cell imaging and tumor therapy. On the other hand, trace detection bio-molecules with large molecular weight still challenging because troublesome treatment SERS substrate using cou...