PURPOSE Hypertension is a mechanism-based toxicity of sorafenib and other cancer therapeutics that inhibit the vascular endothelial growth factor (VEGF) signaling pathway. This prospective, single-center, cohort study characterized ambulatory blood pressure monitoring as an early pharmacodynamic biomarker of VEGF signaling pathway inhibition by sorafenib. EXPERIMENTAL DESIGN Fifty-four normot...

The plotting of cumulative sums (cusums), a technique of proven value in the detection of trends in data collected at intervals of time, may be modified to analyze circadian blood pressure patterns quantitatively. Mean 24-hour ambulatory blood pressure is taken as the reference value and is subtracted from each pressure value. The products of the remainders and the corresponding time intervals ...

We assessed whether home blood pressure monitoring improved the prediction of progression of albuminuria when added to office measurements and compared it with ambulatory blood pressure monitoring in a multiethnic cohort of older people (n=392) with diabetes mellitus, without macroalbuminuria, participating in the telemedicine arm of the Informatics for Diabetes Education and Telemedicine Study...

We examined how different methods and definitions of blood pressure affect the achievement of targets in general practice. There was a wide range in the proportion of treated patients achieving the different target levels recommended by the National Institute for Health and Clinical Excellence, British Hypertension Society and the general medical services contract. Among non-diabetic patients t...

Ambulatory blood pressure measurement, which has been confined to research for many years, is now an accepted investigation in clinical practice [ l ] . In an effort to ensure that the devices meet the requirements of clinical practice the British Hypertension Society (BHs) has published a comprehensive protocol for the evaluation of blood pressure measuring devices with special reference to am...

BACKGROUND This study compared the relative prognostic significance of 24 hour intra-arterial ambulatory systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), and pulse pressure (PP) parameters in middle-aged versus elderly hypertensives. METHODS AND RESULTS A total of 546 subjects aged <60 years and 142 subjects aged >/=60 years who had undergone baseli...

A number of problems relating to clinic measurements of blood pressure may be particularly relevant to elderly patients with isolated systolic hypertension. First, there are large discrepancies in the blood pressure levels measured by these two techniques in the elderly population. Second, while blood pressure is universally accepted as one of the most important risk factors for the development...