Microvascular ischemia in the brain manifests as formation of white matter lesions (WMLs) and lacunae that ultimately result in gait disturbance, cognitive impairment, and dementia.1,2 Most of the changes are caused by cerebral small vessel disease (SVD), but the pathogenesis of cerebral SVD is incompletely understood.3 There is extensive literature describing the relationships between SVD and ...

BACKGROUND Deficits in ambulatory function progress at heterogeneous rates among individuals with Duchenne muscular dystrophy (DMD). The resulting inherent variability in ambulatory outcomes has complicated the design of drug efficacy trials and clouded the interpretation of trial results. We developed a prediction model for 1-year change in the six minute walk distance (6MWD) among DMD patient...

NAKATSUKA, H., IMAI, Y., ABE, K., NAGAI, K., IKEDA, M., SATO, H., SASAKI, S., MINAMI, N., MUNAKATA, M., SAKUMA, H., HASHIMOTO, J. SEKINO, H., IMAI, K. and YOSHINAGA, K. A Population Study of Ambulatory Blood Pressure in a Rural Community in Northern Japan. Tohoku J. Exp. Med., 1991, 163 (2), 119-127 A cross sectional survey was performed on ambulatory blood pressure (ABP) in a rural community i...

BACKGROUND Vitamin D may improve muscle strength through a highly specific nuclear receptor in muscle tissue. OBJECTIVES We investigated whether there is an association between 25-hydroxyvitamin D [25(OH)D] concentrations and lower-extremity function in ambulatory older persons, whether that association differs by activity level, and, if so, whether there is an identifiable threshold in the a...

Calcaneal osteomyelitis with pseudarthrosis after calcaneal fracture is rare, and its treatment challenging. We describe the use of a free fibular osteocutaneous flap to treat 52-year-old man who presented an operation for closed comminuted fracture. The patient was previously treated multiple surgeries antibiotics 8 months, but he not cured. performed radical bone debridement reconstruction au...

BACKGROUND: Heart failure is a highly prevalent disorder that continues to be associated with repeated hospitalizations, high morbidity, and high mortality. Sleep-related breathing disorders with repetitive episodes of asphyxia may adversely affect heart function. The main aims of this study were to determine the prevalence, consequences, and differences in various sleep-related breathing disor...

We are pleased to announce that the Ambulatory Pediatric Association journal will move to a 6 times a year publication, Ambulatory Pediatrics, as of January 2001. Ambulatory Pediatrics will provide a forum for interesting and cutting-edge work in academic general pediatrics. Ambulatory Pediatrics will focus on the education of pediatricians, child health services research, emergency medicine, r...

Aim: As part of the MaReCuM model curriculum at Medical Faculty Mannheim Heidelberg University, a final year rotation in ambulatory care was implemented and augmented to include ambulatory care simulation. In this paper we describe this ambulatory care simulation, the designated competency-based learning objectives, and evaluate the educational effect of the ambulatory care simulation training....

BackgroundFoundational quadruple therapy (RAAS inhibition, Beta-blocker, MRA, SGLT2i) for the management of heart failure reduced ejection fraction (HFrEF) confers significant benefit in terms mortality and (HF) hospitalization. This approach received a strong recommendation CCS/CHFS Heart Failure Guidelines. Recent data indicates that SGLT2i also reduce risk HF hospitalization preserved (HFpEF...