BACKGROUND BRAF V600E is the most frequent genetic alteration in papillary thyroid carcinoma (PTC); there are ongoing conflicts on its association with regional lymph node metastasis. And we aimed to test this association in a referred sample in a single institute in China. METHODS We analyzed BRAF V600E mutational status in the primary lesion of 150 PTC cases in Peking Union Medical College ...

background: beta thalassemia is a common inherited disease, resulting from one or more of 200 different mutations in the beta-globin gene. qazvin province has attracted migrations of several different populations due to industrialization during the past five decades. the aim of this study was to define the molecular spectrum of beta-thalassemia mutations in qazvin province.   methods: ethylen d...

OBJECTIVE Thalassemia is one of the most common genetic disorders worldwide. Cap +1 mutation which causes 'silent beta thalassemia' is present around all ethnic groups of Pakistan. This study was designed to detect the frequency of Cap+1 mutation in Pakistani Population. METHODS Molecular genetic for Cap+1 beta thalassemic mutation was done by extracting DNA from whole blood by using Genomic ...

Background: Hemoglobin D Iran is frequently misdiagnosed as Hb E or Punjab if only one method of screening used. The objective our study was to highlight the importance using two different techniques in diagnosis a hemoglobin variant, case. Hematological parameters heterozygous and compound β/Hb were also compared. Methods: A descriptive carried out on results 52,379 subjects which part thalass...

PURPOSE Tumors from 50% of epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer patients that develop resistance to gefitinib or erlotinib will contain a secondary EGFR T790M mutation. As most patients do not undergo repeated tumor biopsies we evaluated whether EGFR T790M could be detected using plasma DNA. EXPERIMENTAL DESIGN DNA from plasma of 54 patients with known cli...