Crumbs (Crb) is a conserved determinant of apical membrane identity that regulates epithelial morphogenesis in many developmental contexts. In this study, we identify the Crb complex protein Stardust (Sdt) as a target of the E3 ubiquitin ligase Neuralized (Neur) in Drosophila melanogaster Neur interacts with and down-regulates specific Sdt isoforms containing a Neur binding motif (NBM). Using a...

OBJECTIVE This study aimed to investigate the role of microRNA-132 in the epileptogenesis. METHODS Antagomir-132 (Ant-132) was used to silence the expression of miR-132 and non-targeting scrambled sequence (Scr) as a control. Rats were randomly divided into ant-132 group and Scr group in which rats were pretreated with An-132 and Scr, respectively, and then induced temporal lobe epilepsy (TLE...

The anticancer anthracycline compound Adriamycin is a known topoisomerase II inhibitor but is also capable of exerting other cellular consequences. After intercalation, Adriamycin can form covalent adducts with DNA, and the magnitude of these adducts appears to be limited by the cellular availability of formaldehyde. Adducts produced by Adriamycin in the presence of formaldehyde have been well ...

With the Infrared Space Observatory, we conducted 3×3-pixel imaging photometry of twelve luminosity class III stars, which were previously presumed to have dust particles around them, at far infrared wavelengths (60 and 90μm). Eleven out of twelve targets show a peak of excess (above photosphere) far infrared emission at the location of the star, implying that the dust particles are truly assoc...

We study the efficiency of previously proposed stride and sequential prefetching—two promising hardware-based prefetching schemes to reduce readmiss penalties in shared-memory multiprocessors. Although stride accesses dominate in four out of six of the applications we study, we find that sequential prefetching does as well as and in same cases even better than stride prefetching for five applic...

Deep packet inspection (DPI) has become one of the key components of a Network Intrusion Detection System (NIDS) and it compares packet content against a set of rules written in regular expression. The need to keep up with ever-increasing line speed has forced NIDS designers to move to hardware-based implementation where the memory resources are limited. In this paper, we present LBM, a novel a...

The extraordinary actions of a particular father and son became a popular topic of literati writers during late-Qing times and furthermore fueled an ongoing intellectual dispute. The father, Gong Zizhen 龔自珍 (1792–1841), was a renowned scholar credited by Liang Qichao 梁啟超 (1873–1929) for having initiated the important late-Qing intellectual turn from excessive evidential research to discussions ...

Blood glucose measurement is an important feedback in the course of diabetes treatment and prognosis. However, predicting the blood glucose level is not an easy task in the course of insulin treatment. There are many factors influencing the results (internal, environmental and behavioral factors). Previous attempts for predicting high levels of blood glucose utilize data related to insulin prod...

We study the occurrence, visibility, and curvature strength of singularities in dust-containing Szekeres spacetimes (which possess no Killing vectors) with a positive cosmological constant. We find that such singularities can be locally naked, Tipler strong, and develop from a non-zero-measure set of regular initial data. When examined along timelike geodesics, the singularity’s curvature stren...

The scope of this study is to enhance the industry understanding of the sustainable utilization of quarry dust, and to identify any gaps in current knowledge. The term sustainable utilization implies the use of quarry dust to their full potential to meet the needs of the present, while at the same time conserving natural resources and finding ways to minimize the environmental impacts associate...