Antibiotic resistance has become a global threat in which the anthropogenically influenced aquatic environment represents not only reservoir for spread of antibiotic resistant bacteria (ARB) among humans and animals but also an where genes are introduced into natural microbial ecosystems. Wastewater is one sources resistance. The aim this research was evaluation wastewater impact on water envir...

The psychrophilic bacterium Moritella dasanensis strain ArB 0140 was isolated near a glacier in Kongsfjorden, Svalbard Archipelago, Norway. Here we report a 4.89-Mb draft genome sequence of Moritella dasanensis ArB 0140, which could provide comprehensive information on a psychrophilic mechanism in extreme environments.

PURPOSE To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation. METHODS Six weeks after induction of diabetes, C57BL/6 mice were treated with the angiotensin II type 1 receptor (AT1-R) blocker (ARB) telmisartan or valsartan, the AT2-R blocker PD123319, or the NF-kappaB inhibitor dehydroxymethyl...

BACKGROUND Despite strong evidence for beta-blockers and angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) in chronic heart failure (CHF), they have been under-utilised especially in general medical units. We aim to evaluate the effectiveness and feasibility of a physician-targeted quality improvement intervention with education and feedback on the prescript...

薬剤耐性菌（ARB）と耐性遺伝子（ARGs）による水環境の汚染が問題となっている。現在の下水や排水の処理システムは必ずしもARBやARGsの除去を目的としておらず、下水処理場や合併浄化槽などの小規模排水処理システムはARBの主要な排出源であると同時に、ARGsの水平伝播のホットスポットであると考えられている。そのため、ARBへの感染リスクを低減するためには、下水処理場などにおけるARBやARGsの消長を明らかにする必要がある。本稿では、下水処理プロセスの三次処理となる消毒に焦点をあて、現在用いられている各種消毒技術を利用したプロセスの、ARBやARGs削減に関する利点、欠点とその改善に向けた取り組みについて概説した。また、ARBやARGsの水環境中への排出削減に向けて、今後望まれる方策や新技術開発など、更なる研究の方向性についてまとめた。

OBJECTIVE To perform a systematic review of the antihypertensive activity of the angiotensin II AT1 receptor antagonists (ARB). METHODS Studies in which blood pressure (BP) was measured using ambulatory BP monitoring for at least 24 h were collected from MEDLINE. Data for each treatment group, ARB, placebo or the drug used for its comparison were obtained from the selected studies. Only studi...

A nano/ultra-fine grain Al-0.2wt% Zr alloy was produced by accumulated roll bonding (ARB) processafter 10 cycles. The fraction of high angle grain boundaries increased from 8% to 65.4% during 10passes during ARB process. This alloy was subjected to tensile test at different temperatures (523,573and 623 K) and strain rates (0.1 and 0.01 s-1). The optimum condition of temperature and strain rate ...