نتایج جستجو برای: androgen excess
تعداد نتایج: 96984 فیلتر نتایج به سال:
Polycystic ovary syndrome (PCOS), one of the most common and complex endocrine disorders affecting up to 15 % of reproductive age women, is considered a predominantly hyperandrogenic syndrome according to the Androgen Excess Society. It is generally accepted that androgens determine the characteristic features of PCOS; in this context, a hyperactive androgen receptor (AR) at the levels of the G...
Prolactin reverses the inhibitory effects of phammacologi cal doses of androgen on 7,12-dimethylbenz(a)anthracene induced mammary tumor growth (Quadri, S. K. , Kledzik, G. S., and Meites, J. J. NatI. Cancer Inst., 52: 875-878, 1974). To determine whether this effect is due to an alteration in the ability of the tumor cell to bind prolactin, we have quantitated prolactin receptors in androgen-me...
BACKGROUND Congenital adrenal hyperplasia with apparent combined P450C17 and P450C21 deficiency is associated with accumulation of steroid metabolites, indicating impaired activity of 17alpha-hydroxylase and 21-hydroxylase. However, no mutations have been reported in the CYP17 and CYP21 genes, which encode these P450 enzymes. Affected girls are born with ambiguous genitalia, but their circulati...
BACKGROUND Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women. Previous studies have shown that prenatal exposure of female fetuses to androgen can be considered an important factor in the development of PCOS. OBJECTIVES In the present study we aimed to examine the effects of prenatal exposure of female rat fetuses to previously documented doses of test...
Sir, Hagenfeldt et al. (2008) reported that the offspring born to their sample of women with congenital adrenal hyperplasia (CAH) numbered 6 boys and 19 girls. This sex ratio (proportion males) was significantly lower than that of offspring of a control sample. The authors remarked that this result was unexpected. To explore the point further, I examined the sex ratios in the papers cited by th...
Hirsutism, which is a common clinical problem in women of reproductive age, is characterized by excessive growth of terminal hair in the androgen-sensitive skin regions. It is the result of either androgen excess or increased sensitivity of the hair follicles to normal levels of androgens. The therapeutic options of hirsutism can be divided into systemic, topical, and dermato-cosmetic therapies...
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