a general, simple, practical and convenient method has been described for the synthesis of anesthetic drug thiopental using thiourea in the presence of sodium ethoxide. anesthetic drug of thiopental was prepared in two stages; during the first stage, the alkylation of mthyl cyanoacetate was performed which was then to be followed by cyclization. alkylation of methyl cyanoacetate which was perfo...

BACKGROUND The precise mechanism and optimal measure of anesthetic-induced unconsciousness has yet to be elucidated. Preferential inhibition of feedback connectivity from frontal to parietal brain networks is one potential neurophysiologic correlate, but has only been demonstrated in animals or under limited conditions in healthy volunteers. METHODS AND FINDINGS We recruited eighteen patients...

Hemodynamic monitoring is the cornerstone of perioperative anesthetic monitoring. In the unconscious patient, hemodynamic monitoring not only provides information relating to cardiac output, volume status and ultimately tissue perfusion, but also indicates depth of anesthesia and adequacy of pain control. In the 21st century the anesthesiologist has an array of devices to choose from. No single...