background: angiotensin converting enzyme (ace) upregulation in stromal cells of joints affected by rheumatoid arthritis may lead to higher tissue angiotensin ii that is a vasoconstrictor and mitogen factor. to date, the role of angiotensin ii on regulating blood flow in inflamed joints has not been studied.   methods: acute and chronic joint inflammation was induced in rabbits by intra-articul...

Angiotensin-converting enzyme (ACE) plays an important role in regulating blood pressure the body by converting angiotensin-I into angiotensin-II. It is basic component of Renin angiotensin aldosterone system (RAAS), imbalance RAAS may leads to many cardiovascular and renal diseases. There are marketed available drugs for inhibition ACE, but prolonged use some cause progressive side effects. Re...

Arterial compliance is determined by structural factors, such as collagen and elastin, and functional factors, such as vasoactive neurohormones. To determine whether angiotensin II contributes to decreased arterial compliance in patients with heart failure, this study tested the hypothesis that administration of an angiotensin-converting enzyme inhibitor improves arterial compliance. Arterial c...

OBJECTIVE The angiotensin-converting enzyme gene is one of the most studied candidate genes related to atrial fibrillation. Among the polymorphisms of the angiotensin-converting enzyme gene, the 2350 G/A polymorphism (rs4343) is known to have the most significant effects on the plasma angiotensin-converting enzyme concentration. The aim of the present study was to investigate the association of...

The renin-angiotensin system is a far more complex enzymatic cascade than realized previously. Mounting evidence suggests sex-specific differences in the regulation of the renin-angiotensin system and arterial pressure. We examined the hemodynamic responses, angiotensin II receptor subtypes, and angiotensin-converting enzyme 2 gene expression levels after graded doses of angiotensin II in males...