The optic and simulation group at HZB are designing a light source based on the emerging Energy Recovery Linac superconducting technology, the Femto-ScienceFactory (FSF) will provide its users with ultra-bright photons of angstrom wavelength at 6 GeV. The FSF is intended to be a multi-user facility and offer a wide variety of operation modes. A low emittance ∼ 0.1μm rad mode will operate in con...

Ion channels are protein macromolecules that form biological nanotubes across the membranes of living cells. Given many possible geometrical shapes of an ion channel, we propose a computational scheme of selecting the model that best replicates experimental observations, using adaptive Brownian dynamics simulations together with discrete optimization algorithms. Brownian dynamics simulations em...

In Situ Transmission electron microscopy (TEM) is a powerful technique for visualizing dynamic processes at nanometer or Angstrom resolution. It is widely used in studying catalysis, batteries, material transformations, nanoparticle growth, and biological processes. Increasingly, existing TEM camera performance is not able to keep up with the demanding requirements of the cutting-edge in-situ e...

Previous x-ray crystal structures have given insight into the mechanism of transcription and the role of general transcription factors in the initiation of the process. A structure of an RNA polymerase II-general transcription factor TFIIB complex at 4.5 angstrom resolution revealed the amino-terminal region of TFIIB, including a loop termed the "B finger," reaching into the active center of th...