Anionic lipids act as signals for the recruitment of proteins containing cationic clusters to biological membranes. A family of anionic lipids known as the phosphoinositides (PIPs) are low in abundance, yet play a critical role in recruitment of peripheral proteins to the membrane interface. PIPs are mono-, bis-, or trisphosphorylated derivatives of phosphatidylinositol (PI) yielding seven spec...

The X-ray crystal structures were solved for complexes with Torpedo californica acetylcholinesterase of two bivalent tacrine derivative compounds in which the two tacrine rings were separated by 5- and 7-carbon spacers. The derivative with the 7-carbon spacer spans the length of the active-site gorge, making sandwich interactions with aromatic residues both in the catalytic anionic site (Trp84 ...

The paper analyzes the IR spectra of blood plasma from healthy donors, patients with brain infarction and coronary heart disease (CHD). It was found that structure main transport protein – albumin in infarction, CHD representatives control group is almost identical. shown absence changes secondary tertiary albumin, increase binding anionic hydrophobic metabolites dyslipidemia compared to due st...

In the alpha7 nicotinic acetylcholine receptors, we analyze the contribution of mutations E237A and V251T, together with the proline insertion P236', in the conversion of the charge selectivity from cationic to anionic. We show that the triple mutant exhibits spontaneous openings displaying anionic selectivity. Furthermore, at position 251, hydrophilic or even negatively charged residues are co...

In this study, different amounts of MoS2 particles and an anionic surfactant were added to the conventional chromium electroplating bath in order to electrodeposite crack-free chromium coatings and the structure, morphology, tribology and corrosion behavior of the deposited coatings were investigated using X-ray diffraction spectroscopy, scanning electron microscopy, pin on disk ...

The organic deposition particularly asphaltenes has many detrimental effects on the oil industries, such as plugging in pipelines, wellbore and facilities and subsequently, considerable reduction in well productivity.Asphaltenes are the most polar fractions, which they have been dispersed as colloidal clusters in crude oil. The accumulation of these clusters lead to the flocculation of colloids...

The reaction of barium chloride with 2, 6-pyridinedicarboxylic acid in water led to the formation of a novelpolymeric complex formulated as {[Ba2(Hpydc)2(pydc)(H20)3].H20.(H2pydc)}.(I). The crystal structure of (I)was characterized by single crystal X-ray diffraction method. The complex was crystallized in the monoclinicsystem with space group P2/c, with four molecule in unit-cell, e.g Z=4. The...

The in-situ lens-bound protein layer (LBPL) was characterized on hydrogels of varying water content and ionic-binding capacity. The LBPL proved to be critically dependent on the ionic binding capacity of a given hydrogel. On nonionic polymers the LBPL invariably was thin and largely insoluble. Histochemical staining allowed the detection of all major types of tear proteins. Amino acid analysis ...

SLC19A2 is a membrane thiamine transporter expressed in a variety of human tissues, including the gastrointestinal tract. Little is currently known about the structure/function relationship of SLC19A2. We examined the effect of introducing mutations in SLC19A2 identical to those found in thiamine-responsive megaloblastic anemia syndrome (TRMA), on functional activity and membrane expression of ...

We present a combined experimental and theoretical study of ruthenium doped germanium clusters, RuGen(-) (n = 3-12), and their corresponding neutral species. Photoelectron spectra of RuGen(-) clusters are measured at 266 nm. The vertical detachment energies (VDEs) and adiabatic detachment energies (ADEs) are obtained. Unbiased CALYPSO structure searches confirm the low-lying structures of anion...