We previously quantified frailty in aged mice with frailty index (FI) that used specialized equipment to measure health parameters. Here we developed a simplified, noninvasive method to quantify frailty through clinical assessment of C57BL/6J mice (5-28 months) and compared the relationship between FI scores and age in mice and humans. FIs calculated with the original performance-based eight-it...

2. Regional or national MPIs: These are multidimensional poverty measures that have been created by adapting (or using forms of) the method upon which the MPI is based to better address local realities, needs and the data available (these measures use the Alkire-Foster method). Their purpose is to assess multidimensional poverty levels in specific countries or regions in the components most rel...

type 2 diabetes mellitus is associated with increased inflammation and accelerated atherosclerosis. the association of the pro-inflammatory and potentially pro-atherosclerotic molecule, pregnancy associated plasma protein-a (papp-a) with diabetes and vascular diseases remains to be further established. a total of 107 patients with type 2 diabetes and 101 healthy controls participated in this st...

Amaç: Ayak bileği-brakiyal indeksi (ABI), periferik arter hastalığını taramak ve kardiyovasküler prognozu değerlendirmek için önerilen basit bir yöntemdir. Bu çalışmanın amacı; Tip 2 diyabet (T2D) hastalarında ABI’nın glisemik düzey, biyokimyasal parametreler, mikro - makrovasküler komplikasyonlar oksidatif stres (OSI) ile olan ilişkisini irdelemek ayrıca iskemi risk oluşturabilecek faktörleri ...

Cardiovascular disease remains a major cause of morbidity and mortality in the United States. Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that confers a significantly increased risk of myocardial infarction, stroke, and death. Whether cardiovascular risk can be reduced by implementation of secondary prevention therapies (such as antiplatelet therapy, statins, ...

Purpose: To determine the usefulness of pulse oximetry in patients receiving iloprost infusion for treatment of critical limb ischemia unsuitable for revascularization. Material and methods: A total of 42 patients [28 male, mean age 61.80±5.81 years] were included. Patients were those who considered as unsuitable for revascularization based on angiographic study and received single-dose infusio...

OBJECTIVES To investigate whether oxidized low-density lipoprotein is a suitable predictor of peripheral arterial disease severity. The role of oxidized low-density lipoprotein in the pathogenesis of atherosclerosis has already been investigated. Its relevance as a predictor of the appearance and worsening of coronary arterial disease is also well known. However, the same is not true regarding ...

Cardiovascular disease remains a major cause of morbidity and mortality in the United States. Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that confers a significantly increased risk of myocardial infarction, stroke, and death. Whether cardiovascular risk can be reduced by implementation of secondary prevention therapies (such as antiplatelet therapy, statins, ...

OBJECTIVE: The purpose of this study was to evaluate the association between the presence of clinical symptoms of peripheral artery disease and severe renal artery stenosis in patients referred for renal angiography. METHOD: We included 82 patients with clinical suspicion of renovascular hypertension and performed an imaging investigation (renal Doppler ultrasound and/or renal scintigraphy) f...