Noninvasive imaging using radioactive annexin V is an emerging strategy for the assessment of cell death in vivo (F. G. Blankenberg, and H. W. Strauss. Apoptosis, 6: 117-123, 2001.). Therefore, we investigated whether annexin V labeled with the fluorophore Cy5.5 (Cy) could serve as a probe for imaging of tumor apoptosis using near infrared fluorescence (NIRF). We prepared active Cy-annexin (an ...

Radiotherapy is the primary treatment for nasopharyngeal carcinoma while radioresistance can hinder efficient treatment. To explore the role of annexin A1 and its potential mechanisms in radioresistance of nasopharyngeal carcinoma, human nasopharyngeal carcinoma cell line CNE2-sh annexin A1 (knockdown of annexin A1) and the control cell line CNE2-pLKO.1 were constituted and CNE2-sh annexin A1 x...

AN INVESTIGATION INTO THE PHYSIOLOGICAL ROLE OFANNEXIN A11 A. Tomas and S.E. MossDivision of Cell Biology, Institute of Ophthalmology, University College London, London (UK) Annexin A11 is a calcium-dependent phospholipid-binding protein that interacts in vitro with the EF-hand protein, Calcyclin. It is broadly distributed and has the longestN-terminal domain (197 aa) of all known a...

Angiogenesis is essential for tumor growth, invasion, and metastatic spread. Whereas microvessel density (MVD) has been widely used as a measure of tumor-associated angiogenesis, we now wanted to examine the significance of other angiogenic markers, especially vascular proliferation (by Ki-67/factor VIII staining) and the degree of pericyte coverage [by alpha-smooth muscle actin (alpha-SMA)/fac...

UNLABELLED The use of prosthetic devices for correction of velopharyngeal insufficiency (VPI) is an alternative treatment for patients with conditions that preclude surgery and for those individuals with a hypofunctional velopharynx (HV) with a poor prognosis for the surgical repair of VPI. Understanding the role and measuring the outcome of prosthetic treatment of velopharyngeal dysfunction re...

approved: aA'L I Several different types of proteins that are modulated by abscisic acid (ABA) accumulate in developing embryos of maize (Zeamays L). Some of these proteins are specific to the developing seed, such as the storage globulin, GLB1, while others are involved in general responses to water deficit. Here, I report the isolation and characterization of a very distinct family of protein...

10 n asynchronous transfer mode (ATM) networks, multiplexing and switching are performed on 53-byte cells which are transported across the network on virtual channel connections (VCCs) [1]. A virtual path connection (VPC) is a labeled path which can be used to transport, process, and manage a bundle of VCCs. Two levels of cell forwarding are defined: virtual path (VP) and virtual channel (VC), ...

We investigated a specific relationship between the expression of annexin 5 and prolactin in the corpus luteum of pseudopregnant rats, with particular interest in GnRH and apoptosis of luteal cells. The expression of ovarian annexin 5 mRNA was significantly decreased at mid-pseudopregnancy and recovered at the end, whereas it remained low on the corresponding day of pregnancy. The dopamine agon...

OBJECTIVES Annexin A7 is involved in cardiomyocyte membrane organization and Ca(2+)-dependent signalling processes. We investigated the impact of annexin A7 on cardiac electrophysiological properties using an annexin A7-deficient mouse strain (annexin A7(-/-)). METHODS Nineteen adult annexin A7(-/-) and 14 wild-type mice were examined electrophysiologically in vivo by transvenous catheterizat...

Annexin 6 is one of a widely expressed family of calcium-binding proteins found in most mammalian tissues, including the heart. Several studies have implicated annexin 6 in the regulation of intracellular Ca signaling, and it has been shown in vitro to act as a modulator of the sarcoplasmic reticulum Ca-release channel, cardiac L-type calcium channel, and Na/Ca exchanger. To investigate the rol...