The aim of all assisted reproductive techniques (ART) is a live birth of a single healthy baby. Many clinical and laboratory strategies can influence the ART clinical outcomes. In this lecture we try to explore the clinical and laboratory strategies to maximize success in ART. Three are the main issues: 1. optimize the number of oocyte retrieved with an individualized controlled ovarian superov...

In reproductive medicine, the aim is to establish an optimal balance between cost-effectiveness, success rate and safety for the patient. In this thesis, a series of clinical studies are presented that all revolve around the optimisation of ovarian stimulation with GnRH antagonist co-treatment. Basal hormonal levels at the start of ovarian stimulation are mandatory to obtain acceptable pregnanc...

This study was performed to analyze retrospectively outcomes of stimulated in vitro fertilization (IVF) cycles where the gonadotropin-releasing hormone (GnRH) antagonist was omitted on ovulation triggering day. A total of 92 consecutive IVF cycles were included in 65 women who are undergoing ovarian stimulation with recombinant FSH. A GnRH antagonist, cetrorelix 0.25 mg/day, was started when le...

Serotonergic 5-HT2A receptors in cortical and forebrain regions are an important substrate for the neuromodulatory actions of serotonin brain. They have been implicated etiology many neuropsychiatric disorders serve as a target antipsychotic, antidepressant, anxiolytic drugs. Positron emission tomography imaging using suitable radioligands can be applied vivo quantification receptor densities o...

OBJECTIVE To compare long GnRH agonist with GnRH antagonist protocol in poor responders. MATERIALS AND METHODS Medical charts of 531 poor responder women undergoing in-vitro fertilization (IVF) cycle at Zeynep Kamil Maternity and Children's Hospital, IVF Center were retrospectively analysed. Those who received at least 300 IU/daily gonadotropin and had ≤3 oocytes retrieved were enrolled in th...