background:the current study aimed at evaluating the association between thyroid-stimulating hormone (tsh) level in upper normal limits with metabolic syndrome, modifiable risk factor for cardiovascular disease, and its components according to adult treatment panel iii of national cholesterol education program. methods: the current cross sectional study recruited 82 patients with euthyroid over...

objectives the aim of this study was to evaluate the effect of cranberry extract on some components of metabolic syndrome. patients and methods in a randomized, double-blind placebo-controlled clinical trial, 48 obese and overweight females diagnosed with ms were assigned into two groups to receive cranberry supplement or placebo for an eight-week period. serum glucose, lipoproteins, inflammato...

no abstract

Evidence suggests that transcranial direct current stimulation (tDCS) modulates conditioned fear memories and has effects on cognitive flexibility via the dopaminergic system. This study examines whether modulation of scopolamine-induced memory deficit by anodal tDCS could be mediated The male NMRI mice received scopolamine, 30 min before conditioning, showed impaired contextual retention. Mice...

At present the prevalence of heart failure rises along with aging of the population. Current heart failure therapeutic options are directed towards disease prevention via neurohormonal antagonism (beta-blockers, angiotensin converting enzyme inhibitors and/or angiotensin receptor blockers and aldosterone antagonists), symptomatic treatment with diuretics and digitalis and use of biventricular p...

Arachidonic acid metabolites are vital for the proper control of renal haemodynamics and, when not properly controlled, can contribute to renal vascular injury and end-stage renal disease. Three major enzymatic pathways, COX (cyclo-oxygenase), CYP450 (cytochrome P450) and LOX (lipoxygenase), are responsible for the metabolism of arachidonic acid metabolites to bioactive eicosanoids. These eicos...

The metabolic syndrome is a common precursor of cardiovascular disease and type 2 diabetes that is characterized by the clustering of insulin resistance, dyslipidemia, and increased blood pressure. In humans, mutations in the peroxisome proliferator-activated receptor-gamma (PPARgamma) have been reported to cause the full-blown metabolic syndrome, and drugs that activate PPARgamma have proven t...

Insulin can trigger metabolic as well as mitogenic effects, the latter being pharmaceutically undesirable. An understanding of the structure/function relationships between insulin receptor (IR) binding and mitogenic/metabolic signalling would greatly facilitate the preclinical development of new insulin analogues. The occurrence of ligand agonism and antagonism is well described for G protein-c...

When distilled water from a tin-lined still served as the plating diluent, cells of Aerobacter aerogenes developed symptoms of metabolic injury as evidenced by increased counts on supplemented, as compared with minimal, plating medium. Cysteine was as effective as yeast extract as a supplement to the minimal medium in increasing the viable count. Mg(++) and, to a lesser extent, phosphate buffer...

The metabolic syndrome is a common precursor of cardiovascular disease and type 2 diabetes that is characterized by the clustering of insulin resistance, dyslipidemia, and increased blood pressure. In humans, mutations in the peroxisome proliferator–activated receptor(PPAR ) have been reported to cause the full-blown metabolic syndrome, and drugs that activate PPAR have proven to be effective a...