The involvement of the vascular system in malignancy encompasses not only angiogenesis, but also systemic hypercoagulability and a pro-thrombotic state, and there is increasing evidence that pathways of blood coagulation and angiogenesis are reciprocally linked. In fact, cancer atients often display hypercoagulability resulting in markedly increased thromboembolism, which requires anti-coagulan...

An oxo-bridged diruthenium(III) complex containing pyrazolato and pyrazole ligands is stable against ascorbic-acid reduction, induces apoptosis (60%, 48 h) against HeLa cells at 10 microM level and exhibits promising anti-angiogenic activity at its sub-cytotoxic concentrations. Other mononuclear ruthenium(III) complexes containing pyrazole ligands [Ru(pz)(4)X(2)](+) exhibit dual anti-angiogenic...

To reduce the pro-angiogenic effects of sEH inhibition, a structure-activity relationship (SAR) study was performed by incorporating structural features of the anti-angiogenic multi-kinase inhibitor sorafenib into soluble epoxide hydrolase (sEH) inhibitors. The structural modifications of this series of molecules enabled the altering of selectivity towards the pro-angiogenic kinases C-RAF and v...

There was a radical change in the first-line management of advanced NSCLC with negative genetic oncological drive last 5 years. Immune checkpoint inhibition is currently recommended for such group patients by major international guidelines devoted to lung cancer, as long there no contraindication. The recommendations came single agent immune inhibitor, combination an inhibitor chemotherapy opti...

DLL4 is a ligand for the Notch family of receptors. DLL4 has many important functions in normal development and tissue homeostasis, including roles in the immune system, the gastro-intestinal tract, and in vascular development. Because of the importance of Notch signaling in stem cell biology, DLL4 has been investigated for its role in the maintenance and proliferation of cancer stem cells (CSC...

In article 1600229, Shilong Wang, Rongrong Zhu, Yechang Qian, and co-workers investigate the anti-metastatic and anti-angiogenic effects of SiO2@LDH (LDH: layered double hydroxide) loaded with etoposide (VP16). SiO2@LDH has very suitable qualities as drug delivery agent and enhances the anti-metastatic action of VP16 both in vitro and in vivo. Enhanced anti-angiogenic efficacy is also proven wh...